Ammonia
Suppliers
Names
[ CAS No. ]:
7664-41-7
[ Name ]:
Ammonia
[Synonym ]:
amoniak
Anhydrous ammonia
ammoniaca
spirit of hartshorn
azane
Ammonia
EINECS 231-635-3
MFCD00011418
AZAN
NH3
Nitro-Sil
am-fol
r717
Chemical & Physical Properties
[ Density]:
1.023 g/mL at 25 °C
[ Boiling Point ]:
-33.4±9.0 °C at 760 mmHg
[ Melting Point ]:
−78 °C(lit.)
[ Molecular Formula ]:
H3N
[ Molecular Weight ]:
17.031
[ Flash Point ]:
52 °F
[ Exact Mass ]:
17.026548
[ PSA ]:
3.24000
[ LogP ]:
0.32390
[ Vapour density ]:
0.6 (vs air)
[ Vapour Pressure ]:
5992.5±0.0 mmHg at 25°C
[ Index of Refraction ]:
1.355
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BO0875000
- CHEMICAL NAME :
- Ammonia
- CAS REGISTRY NUMBER :
- 7664-41-7
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 62
- MOLECULAR FORMULA :
- H3-N
- MOLECULAR WEIGHT :
- 17.04
- WISWESSER LINE NOTATION :
- ZH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 15 uL/kg
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of esophagus
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 20 ppm
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - ulcerated nasal septum Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 5000 ppm/5M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 132 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2000 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4230 ppm/1H
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 7 gm/m3/1H
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - excitement
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 7 gm/m3/1H
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - excitement
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 5000 ppm/5M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 ppm/6H/5D-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Blood - other changes Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 455 mg/m3/8H/90D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 960 mg/m3/4H/17W-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 711 ppm/6H/14D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 470 mg/m3/8H/90D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 470 mg/m3/8H/90D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - corneal damage Sense Organs and Special Senses (Eye) - effect, not otherwise specified
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - pig
- DOSE/DURATION :
- 145 ppm/5W-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 470 mg/m3/8H/90D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1680 mg/kg/24W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- REFERENCE :
- BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966- Volume(issue)/page/year: 27(6),102,1974 *** REVIEWS *** ACGIH TLV-STEL 24 mg/m3 (35 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 17 mg/m3 (25 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A094-501 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 25 ppm (18 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,11,1971 OSHA PEL (Gen Indu):8H TWA 50 ppm (35 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 50 ppm (35 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 50 ppm (35 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 50 ppm (35 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 25 ppm (18 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 25 ppm (18 mg/m3);STEL 35 ppm (27 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 50 ppm (35 mg/m3) JAN 1993 OEL-BELGIUM:TWA 25 ppm (17 mg/m3);STEL 35 ppm (24 mg/m3) JAN 1993 OEL-DENMARK:TWA 25 ppm (18 mg/m3) JAN 1993 OEL-FINLAND:TWA 25 ppm (18 mg/m3);STEL 40 ppm (30 mg/m3) JAN 1993 OEL-FRANCE:TWA 25 ppm (18 mg/m3);STEL 50 ppm (36 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (35 mg/m3) JAN 1993 OEL-HUNGARY:TWA 18 mg/m3;STEL 27 mg/m3 JAN 1993 OEL-INDIA:TWA 25 ppm (18 mg/m3);STEL 35 ppm (27 mg/m3) JAN 1993 OEL-JAPAN:TWA 25 ppm (17 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 25 ppm (18 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 50 ppm (30 mg/m3) JAN 1993 OEL-POLAND:TWA 20 mg/m3;STEL 20 mg/m3 JAN 1993 OEL-RUSSIA:TWA 25 ppm;STEL 20 mg/m3 JAN 1993 OEL-SWEDEN:TWA 25 ppm (18 mg/m3);STEL 50 ppm (35 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 25 ppm (18 mg/m3);STEL 50 ppm (36 mg/m3) JAN 1993 OEL-THAILAND:TWA 50 ppm (35 mg/m3) JAN 1993 OEL-TURKEY:TWA 25 ppm (35 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 25 ppm (18 mg/m3);STEL 35 ppm (27 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO AMMONIA-air:10H TWA 25 ppm;STEL 35 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 05250 No. of Facilities: 115139 (estimated) No. of Industries: 363 No. of Occupations: 198 No. of Employees: 1168429 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 05250 No. of Facilities: 42116 (estimated) No. of Industries: 270 No. of Occupations: 174 No. of Employees: 805962 (estimated) No. of Female Employees: 287974 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H221-H280-H314-H331-H410
[ Precautionary Statements ]:
P210-P261-P273-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;Gloves;Goggles;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
F:Flammable
[ Risk Phrases ]:
R10;R11;R23/24/25;R36/37/38;R39/23/24/25
[ Safety Phrases ]:
S26-S7-S45-S36/37/39-S16-S9-S61
[ RIDADR ]:
UN 1219 3/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
BO0875000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
2814100000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2814100000
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