Ebelactone A

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Names

[ CAS No. ]:
76808-16-7

[ Name ]:
Ebelactone A

[Synonym ]:
3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC ACID 1,3-LACTONE
3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECANOIC-1,3-LACTONE
ebelactone a microbial
3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC 1,3-LACTONE
3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECEN-3-OLIDE
3,11-DIHYDROXY-2,4,5,6,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC 1,3-LACTONE

Chemical & Physical Properties

[ Density]:
1.011g/cm3

[ Boiling Point ]:
462.8ºC at 760 mmHg

[ Molecular Formula ]:
C20H34O4

[ Molecular Weight ]:
338.48200

[ Flash Point ]:
152.8ºC

[ Exact Mass ]:
338.24600

[ PSA ]:
63.60000

[ LogP ]:
3.76870

[ Index of Refraction ]:
1.483

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RQ7730000
CHEMICAL NAME :
2-Oxetanone, 4-(8-hydroxy-1,3,5,7,9-pentamethyl-6-oxo-3-undecenyl) -3-methyl-, (3S-(3- alpha,4-beta(1R*,3E,5S*,7R*,8S*,9S*)))-
CAS REGISTRY NUMBER :
76808-16-7
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H34-O4
MOLECULAR WEIGHT :
338.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,1594,1980

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RQ7730000

Articles

Structural studies on ebelactone A and B, esterase inhibitors produced by actinomycetes.

J. Antibiot. 35 , 1495-1499, (1982)

Biosynthetic studies of ebelactone A and B by 13C NMR spectrometry.

J. Antibiot. 35 , 1670, (1982)

Biosynthetic pathways of ebelactone A and B were studied by 13C NMR spectroscopy. By using 13C labeled compounds as precursors it was determined that ebelactone A was derived from one molecule of acet...

Effects of ebelactone B, a lipase inhibitor, on intestinal fat absorption in the rat.

J. Enzym. Inhib. 10(1) , 57-63, (1996)

Ebelactones A and B, natural products from Streptomyces aburaviensis are potent inhibitors of pancreatic lipase. Lipase is the key enzyme required for the absorption of dietary triglycerides (TG). Ebe...


More Articles

Related Compounds

  • actinoplanone A
  • Thapsuine A
  • Apocynol A
  • (2S)-N-[(2S,5S,8S,11R,12S,15S,18S,21R)-5-[(3-bromo-4-methoxyphenyl)methyl]-2-[(2S)-butan-2-yl]-15-[3-(carbamoylamino)propyl]-21-hydroxy-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]-2-(butanoyla
  • Pseudoanguillosporin A
  • Digitoside A