Ronidazole

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Names

[ Name ]:
Ronidazole

[Synonym ]:
(1-Methyl-5-nitro-1H-imidazol-2-yl)methyl carbamate
Ridazole
Carbamic Acid (1-Methyl-5-nitroimidazol-2-yl)methyl Ester
Ridzol P
Dugro
(1-Methyl-5-nitroimidazole-2-yl)methyl Carbamate
2-Carbamoyloxymethyl-1-methyl-5-nitro-imidazol
1-Methyl-2-[(carbamoyloxy)methyl]-5-nitroimidazole
Ridzol
1-Methyl-5-nitroimidazole-2-methanol Carbamate (Ester)
1H-Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate (ester)
MCMN
2-carbamoyloxymethyl-1-methyl-5-nitro-1H-imidazole
Ronidazole
Ronidazol
EINECS 231-675-1

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
502.3±30.0 °C at 760 mmHg

[ Melting Point ]:
167-169°

[ Molecular Formula ]:
C₆H₈N₄O₄

[ Molecular Weight ]:
200.152

[ Flash Point ]:
257.6±24.6 °C

[ Exact Mass ]:
200.054550

[ PSA ]:
115.96000

[ LogP ]:
-0.45

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.651

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI6803000

CHEMICAL NAME :: Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate (ester)

CAS REGISTRY NUMBER :: 7681-76-7

BEILSTEIN REFERENCE NO. :: 0886221

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C6-H8-N4-O4

MOLECULAR WEIGHT :: 200.18

WISWESSER LINE NOTATION :: T5N CNJ A1 B1OVZ ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,289,1976

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
NI6803000

[ HS Code ]:
2933290090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Determination of nitroimidazole residues in aquaculture tissue using ultra high performance liquid chromatography coupled to tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 960 , 105-15, (2014)

An UHPLC-MS/MS method was developed for the quantitative confirmatory analysis of residues of nitroimidazole drugs (dimetridazole, ipronidazole, metronidazole, ornidazole and ronidazole) and their cor...

Simultaneous determination of 15 nitroimidazoles in cosmetics by HPLC coupled with electrospray ionization- tandem mass spectrometry.

J. AOAC Int. 97(6) , 1538-45, (2015)

A sensitive and reliable analytical method based on HPLC/MSIMS has been developed for the simultaneous determination of 15 nitroimidazoles in cosmetics. A diversity of cosmetic samples, including powd...

Tritrichomonas foetus infection in cats with diarrhoea in a rescue colony in Italy.

J. Feline Med. Surg. 11(2) , 131-4, (2009)

Faecal samples from 74 cats with chronic large bowel diarrhoea that were living in a rescue colony in Italy, were submitted for assessment of Tritrichomonas foetus by direct microscopy of faecal smear...