methsuximide

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Names

[ CAS No. ]:
77-41-8

[ Name ]:
methsuximide

[Synonym ]:
Celontin
1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dion
1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione
mesuximid
Mesuximide
Mesuximida
Metsuccimide
Petinutin
methsuximide
Methsuximid
Mesuximidum

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Boiling Point ]:
489.2ºC at 760 mmHg

[ Melting Point ]:
52-53°

[ Molecular Formula ]:
C12H13NO2

[ Molecular Weight ]:
203.23700

[ Flash Point ]:
191.7ºC

[ Exact Mass ]:
203.09500

[ PSA ]:
37.38000

[ LogP ]:
1.27090

[ Index of Refraction ]:
1.692

[ Storage condition ]:
Refrigerator

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WN2625000
CHEMICAL NAME :
Succinimide, N,2-dimethyl-2-phenyl-
CAS REGISTRY NUMBER :
77-41-8
BEILSTEIN REFERENCE NO. :
0168315
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H13-N-O2
MOLECULAR WEIGHT :
203.26
WISWESSER LINE NOTATION :
T5VNVTJ B1 D1 DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 6,740,1954 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
1006 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6158 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 876 (estimated) No. of Female Employees: 408 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H412

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (+/-)-2-Methyl-2-phenylbutanedioic acid
  • methylamine

DownStream

  • (3S)-1,3-dimethyl-3-phenylpyrrolidine-2,5-dione

Related Compounds

  • Methsuximide
  • 2-chloro-N-(2,4-diethyl-6-methyl-phenyl)-N-(ethoxymethyl)acetamide
  • 2-(4-methylpiperazin-1-yl)-4-(1-piperidyl)aniline
  • [2-(2-bromophenoxy)-1,1,2,2-tetrafluoro-ethyl]-trimethyl-silane
  • [2-(2,4-dichlorophenoxy)-1,1,2,2-tetrafluoro-ethyl]-trimethyl-silane
  • 3-(2-chloro-5-methoxy-phenyl)-6-(2-chlorophenyl)-1,2,4,5-tetrazine
  • (4R,8S,9S,13R,19S)-19-fluoro-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-diene-11,16-dione
  • 2-[4-[2-[(4-chlorobenzoyl)amino]-1-hydroxy-ethyl]phenoxy]-2-methyl-propanoic acid
  • (9R,10S,13S,16S,17R)-9-fluoro-17-hydroxy-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-17-carboxylic acid
  • [(1S,2S,4S,5R,6R,8R,10S,11R,12S)-11-chloro-6,10-dihydroxy-4,12-dimethyl-15-oxo-5-propanoyloxy-6-pentacyclo[9.8.0.02,8.05,8.012,17]nonadeca-13,16-dienyl]methyl propanoate
  • 2-[[(2R)-2-amino-2-carboxy-ethyl]disulfanyl]-3-[4-[(6-methoxy-1-methyl-benzimidazol-2-yl)methoxy]phenyl]propanoic acid
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