methsuximide

Modify Date: 2024-01-05 10:37:46

methsuximide Structure
methsuximide structure
Common Name methsuximide
CAS Number 77-41-8 Molecular Weight 203.23700
Density 1.59g/cm3 Boiling Point 489.2ºC at 760 mmHg
Molecular Formula C12H13NO2 Melting Point 52-53°
MSDS N/A Flash Point 191.7ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of methsuximide


Methsuximide is an anticonvulsant agent. Methsuximide is effective in petit mal, psychomotor and focal motor attacks[1].

 Names

Name 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
Synonym More Synonyms

 methsuximide Biological Activity

Description Methsuximide is an anticonvulsant agent. Methsuximide is effective in petit mal, psychomotor and focal motor attacks[1].
Related Catalog
References

[1]. MARY LOUISE SCHOLL, et al. Celontin - a New Anticonvulsant.

 Chemical & Physical Properties

Density 1.59g/cm3
Boiling Point 489.2ºC at 760 mmHg
Melting Point 52-53°
Molecular Formula C12H13NO2
Molecular Weight 203.23700
Flash Point 191.7ºC
Exact Mass 203.09500
PSA 37.38000
LogP 1.27090
Index of Refraction 1.692
Storage condition Refrigerator

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WN2625000
CHEMICAL NAME :
Succinimide, N,2-dimethyl-2-phenyl-
CAS REGISTRY NUMBER :
77-41-8
BEILSTEIN REFERENCE NO. :
0168315
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H13-N-O2
MOLECULAR WEIGHT :
203.26
WISWESSER LINE NOTATION :
T5VNVTJ B1 D1 DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 6,740,1954 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
1006 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6158 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 876 (estimated) No. of Female Employees: 408 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H412
Precautionary Statements P301 + P312 + P330
RIDADR NONH for all modes of transport

 Synthetic Route

~%

methsuximide Structure

methsuximide

CAS#:77-41-8

Literature: Vystrcil; Cerny Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 804,807 Show Details Miller; Long Journal of the American Chemical Society, 1951 , vol. 73, p. 4895,4897

 Synonyms

Celontin
1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dion
1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione
mesuximid
Mesuximide
Mesuximida
Metsuccimide
Petinutin
methsuximide
Methsuximid
Mesuximidum
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