1,3-Dibromo-5,5-dimethylhydantoin
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Names
[ CAS No. ]:
77-48-5
[ Name ]:
1,3-Dibromo-5,5-dimethylhydantoin
[Synonym ]:
N,N'-dibromo-5,5-dimethyl hydantoin
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione
2,4-Imidazolidinedione, 1,3-dibromo-5,5-dimethyl-
DIBROMANTIN
3-DibroMo-5
DDH
1,3-dibromo-5,5-dimethyl-hydantoin
1,3-Dibromo-5,5-dimethyl-2,4-imidazolidinedione
1,3-Dibromo-5,5-dimethyl hydantoin
EINECS 201-030-9
1,3-Dibromo-5,5-dimethylhydantoin
Bromotoin
dibromantine
BROMTOIN
DIBROMATIN
1,3-Dibromo-5
DBDMH
1,3-dibromo-4,4-dimethyl-2,5-dioxoimidazolidine
MFCD00003189
Chemical & Physical Properties
[ Density]:
2.2±0.1 g/cm3
[ Boiling Point ]:
250.2±23.0 °C at 760 mmHg
[ Melting Point ]:
197-199 °C (dec.)(lit.)
[ Molecular Formula ]:
C5H6Br2N2O2
[ Molecular Weight ]:
285.921
[ Flash Point ]:
105.1±22.6 °C
[ Exact Mass ]:
283.879578
[ PSA ]:
40.62000
[ LogP ]:
1.68
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.622
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MU0686000
- CHEMICAL NAME :
- Hydantoin, 1,3-dibromo-5,5-dimethyl-
- CAS REGISTRY NUMBER :
- 77-48-5
- BEILSTEIN REFERENCE NO. :
- 0146024
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C5-H6-Br2-N2-O2
- MOLECULAR WEIGHT :
- 285.95
- WISWESSER LINE NOTATION :
- T5NVNV EHJ AE CE E1 E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(10),108,1971
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29 gm/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0281-0382
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 20 gm/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0581-0382 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 52 mg/kg/17W-I
- TOXIC EFFECTS :
- Endocrine - evidence of thyroid hypofunction
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(10),108,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83854 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 124 (estimated)
Safety Information
[ Symbol ]:
GHS03, GHS05, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H272-H301-H314-H317-H410
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P210-P220-P280-P305 + P351 + P338-P370 + P378
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
C:Corrosive
[ Risk Phrases ]:
R22;R34;R50;R8
[ Safety Phrases ]:
S17-S26-S36/37/39-S45-S60-S61
[ RIDADR ]:
UN 3087 5.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
MU0686000
[ Packaging Group ]:
II
[ Hazard Class ]:
5.1
[ HS Code ]:
29332100
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Pharm. Biomed. Anal. 28(2) , 337-43, (2002)
USP 2000 (The United States Pharmacopeia, Rockville, MD, 24th ed., 2000, pp. 1514-1515) and PH. EUR. 1997 (European Pharmacopoeia, 3rd ed., Council of Europe, Strasbourg, 1997, p. 1459) dissolve selen...
Pharm. Weekbl. Sci. 10(2) , 90-2, (1988)
A titrimetric method is described for the determination of three acetylenic hypnotics, namely ethchlorvynol, ethinamate, and methylpentynol carbamate, in bulk and in dosage forms. The method involves ...
Pharmazie 57(1) , 45-8, (2002)
PH. EUR. 2002 uses elemental bromine performing iron limit tests for maleic acid (iron 5 ppm) and titanium dioxide (iron 200 ppm). 1,3-Dibromo-5,5-dimethylhydantoin (DBH) can replace bromine water. Fo...