1,3-Dibromo-5,5-dimethylhydantoin

Modify Date: 2024-01-01 19:09:24

1,3-Dibromo-5,5-dimethylhydantoin structure	Common Name	1,3-Dibromo-5,5-dimethylhydantoin
	CAS Number	77-48-5	Molecular Weight	285.921
	Density	2.2±0.1 g/cm3	Boiling Point	250.2±23.0 °C at 760 mmHg
	Molecular Formula	C₅H₆Br₂N₂O₂	Melting Point	197-199 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	105.1±22.6 °C
	Symbol	GHS03, GHS05, GHS06, GHS09	Signal Word	Danger

Use of 1,3-Dibromo-5,5-dimethylhydantoin

1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,3-Dibromo-5,5-dimethylhydantoin
Synonym	More Synonyms

Description	1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	2.2±0.1 g/cm3
Boiling Point	250.2±23.0 °C at 760 mmHg
Melting Point	197-199 °C (dec.)(lit.)
Molecular Formula	C₅H₆Br₂N₂O₂
Molecular Weight	285.921
Flash Point	105.1±22.6 °C
Exact Mass	283.879578
PSA	40.62000
LogP	1.68
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.622

1,3-Dibromo-5,5-dimethylhydantoin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MU0686000

CHEMICAL NAME :: Hydantoin, 1,3-dibromo-5,5-dimethyl-

CAS REGISTRY NUMBER :: 77-48-5

BEILSTEIN REFERENCE NO. :: 0146024

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H6-Br2-N2-O2

MOLECULAR WEIGHT :: 285.95

WISWESSER LINE NOTATION :: T5NVNV EHJ AE CE E1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(10),108,1971

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29 gm/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0281-0382

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0581-0382 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 mg/kg/17W-I

TOXIC EFFECTS :: Endocrine - evidence of thyroid hypofunction

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(10),108,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83854 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 124 (estimated)

Symbol	GHS03, GHS05, GHS06, GHS09
Signal Word	Danger
Hazard Statements	H272-H301-H314-H317-H410
Precautionary Statements	Missing Phrase - N15.00950417-P210-P220-P280-P305 + P351 + P338-P370 + P378
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive
Risk Phrases	R22;R34;R50;R8
Safety Phrases	S17-S26-S36/37/39-S45-S60-S61
RIDADR	UN 3087 5.1/PG 2
WGK Germany	3
RTECS	MU0686000
Packaging Group	II
Hazard Class	5.1
HS Code	29332100

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HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Determination of selenium sulfide using 1,3-dibromo-5,5-dimethylhydantoin (DBH). Analytical methods of pharmacopeias with DBH in respect to environmental and economical concern Part 11.

J. Pharm. Biomed. Anal. 28(2) , 337-43, (2002)

USP 2000 (The United States Pharmacopeia, Rockville, MD, 24th ed., 2000, pp. 1514-1515) and PH. EUR. 1997 (European Pharmacopoeia, 3rd ed., Council of Europe, Strasbourg, 1997, p. 1459) dissolve selen...

Titrimetric determination of acetylenic hyponotics using organic brominating agents.

Pharm. Weekbl. Sci. 10(2) , 90-2, (1988)

A titrimetric method is described for the determination of three acetylenic hypnotics, namely ethchlorvynol, ethinamate, and methylpentynol carbamate, in bulk and in dosage forms. The method involves ...

Determination of iron limiting values according to PH. EUR. using 1,3-dibromo-5,5-dimethylhydantoin (DBH) instead of elemental bromine. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern. Part 8.

Pharmazie 57(1) , 45-8, (2002)

PH. EUR. 2002 uses elemental bromine performing iron limit tests for maleic acid (iron 5 ppm) and titanium dioxide (iron 200 ppm). 1,3-Dibromo-5,5-dimethylhydantoin (DBH) can replace bromine water. Fo...

N,N'-dibromo-5,5-dimethyl hydantoin

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

2,4-Imidazolidinedione, 1,3-dibromo-5,5-dimethyl-

DIBROMANTIN

3-DibroMo-5

DDH

1,3-dibromo-5,5-dimethyl-hydantoin

1,3-Dibromo-5,5-dimethyl-2,4-imidazolidinedione

1,3-Dibromo-5,5-dimethyl hydantoin

EINECS 201-030-9

1,3-Dibromo-5,5-dimethylhydantoin

Bromotoin

dibromantine

BROMTOIN

DIBROMATIN

1,3-Dibromo-5

DBDMH

1,3-dibromo-4,4-dimethyl-2,5-dioxoimidazolidine

MFCD00003189

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1,3-Dibromo-5,5-dimethylhydantoin
Price: ￥88.0/100g ￥218.0/500g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3-Dibromo-5,5-dimethylhydantoin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 1, 3-Dibromo-5, 5-Dimethylhydantoin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 77-48-5 1,3-Dibromo-5,5-dimethylhydantoin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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