1,3-Dibromo-5,5-dimethylhydantoin

Modify Date: 2026-07-19 18:16:48

1,3-Dibromo-5,5-dimethylhydantoin structure	Common Name	1,3-Dibromo-5,5-dimethylhydantoin
	CAS Number	77-48-5	Molecular Weight	285.921
	Density	2.2±0.1 g/cm3	Boiling Point	250.2±23.0 °C at 760 mmHg
	Molecular Formula	C₅H₆Br₂N₂O₂	Melting Point	197-199 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	105.1±22.6 °C
	Symbol	GHS03, GHS05, GHS06, GHS09	Signal Word	Danger

Use of 1,3-Dibromo-5,5-dimethylhydantoin

1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Summary: 1,3-Dibromo-5,5-dimethylhydantoin, with Chinese name as 1,3-二溴-5,5-二甲基海因, CAS number 77-48-5, and molecular formula C5H6Br2N2O2, with molecular weight 285.921. It appears as a white powder with a melting point of 197-199°C (dec.) and a boiling point of 250.2±23.0 °C. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	1,3-Dibromo-5,5-dimethylhydantoin
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	2.2±0.1 g/cm3
Boiling Point	250.2±23.0 °C at 760 mmHg
Melting Point	197-199 °C (dec.)(lit.)
Molecular Formula	C₅H₆Br₂N₂O₂
Molecular Weight	285.921
Flash Point	105.1±22.6 °C
Exact Mass	283.879578
PSA	40.62000
LogP	1.68
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.622
InChIKey	VRLDVERQJMEPIF-UHFFFAOYSA-N
SMILES	CC1(C)C(=O)N(Br)C(=O)N1Br

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

1,3-Dibromo-5,5-dimethylhydantoin MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MU0686000

CHEMICAL NAME :: Hydantoin, 1,3-dibromo-5,5-dimethyl-

CAS REGISTRY NUMBER :: 77-48-5

BEILSTEIN REFERENCE NO. :: 0146024

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H6-Br2-N2-O2

MOLECULAR WEIGHT :: 285.95

WISWESSER LINE NOTATION :: T5NVNV EHJ AE CE E1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(10),108,1971

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29 gm/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0281-0382

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0581-0382 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 mg/kg/17W-I

TOXIC EFFECTS :: Endocrine - evidence of thyroid hypofunction

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(10),108,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83854 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 124 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS03, GHS05, GHS06, GHS09
Signal Word	Danger
Hazard Statements	H272-H301-H314-H317-H410
Precautionary Statements	Missing Phrase - N15.00950417-P210-P220-P280-P305 + P351 + P338-P370 + P378
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive
Risk Phrases	R22;R34;R50;R8
Safety Phrases	S17-S26-S36/37/39-S45-S60-S61
RIDADR	UN 3087 5.1/PG 2
WGK Germany	3
RTECS	MU0686000
Packaging Group	II
Hazard Class	5.1
HS Code	29332100

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

5,5-Dimethylimi...

CAS#:77-71-4

~99%

1,3-Dibromo-5,5...

CAS#:77-48-5

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Literature: ALBEMARLE CORPORATION Patent: EP1250045 B1, 2003 ;

1,3-Dichloro-5,...

CAS#:118-52-5

5,5-Dimethylimi...

CAS#:77-71-4

1,3-Dibromo-5,5...

CAS#:77-48-5

Learn More

Literature: US2868787 , ;

Sodium cyanide

CAS#:143-33-9

Acetone

CAS#:67-64-1

1,3-Dibromo-5,5...

CAS#:77-48-5

Learn More

Literature: Anales de la Asociacion Quimica Argentina (1921-2001), , vol. 41, p. 153

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 4
CAS#:77-71-4 5,5-Dimethylimi... CAS#:118-52-5 1,3-Dichloro-5,... CAS#:143-33-9 Sodium cyanide CAS#:67-64-1 Acetone
DownStream 10
CAS#:27973-29-1 1,6-Dibromopyrene CAS#:38303-35-4 1,8-Dibromopyrene CAS#:108-94-1 Cyclohexanone CAS#:663954-33-4 1-N,1-N,6-N,6-N...
CAS#:142827-48-3 1-N,1-N,8-N,8-N... CAS#:939-26-4 2-(brommethyl)n... CAS#:91394-66-0 Acetamide,N-(4-... CAS#:100-39-0 Benzyl bromide
CAS#:2859-78-1 4-Bromoveratrole CAS#:874-98-6 3-methoxybenzyl...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Determination of selenium sulfide using 1,3-dibromo-5,5-dimethylhydantoin (DBH). Analytical methods of pharmacopeias with DBH in respect to environmental and economical concern Part 11.

J. Pharm. Biomed. Anal. 28(2) , 337-43, (2002)

USP 2000 (The United States Pharmacopeia, Rockville, MD, 24th ed., 2000, pp. 1514-1515) and PH. EUR. 1997 (European Pharmacopoeia, 3rd ed., Council of Europe, Strasbourg, 1997, p. 1459) dissolve selen...

Titrimetric determination of acetylenic hyponotics using organic brominating agents.

Pharm. Weekbl. Sci. 10(2) , 90-2, (1988)

A titrimetric method is described for the determination of three acetylenic hypnotics, namely ethchlorvynol, ethinamate, and methylpentynol carbamate, in bulk and in dosage forms. The method involves ...

Determination of iron limiting values according to PH. EUR. using 1,3-dibromo-5,5-dimethylhydantoin (DBH) instead of elemental bromine. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern. Part 8.

Pharmazie 57(1) , 45-8, (2002)

PH. EUR. 2002 uses elemental bromine performing iron limit tests for maleic acid (iron 5 ppm) and titanium dioxide (iron 200 ppm). 1,3-Dibromo-5,5-dimethylhydantoin (DBH) can replace bromine water. Fo...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Name: Adrenergic beta2 receptor (ADRB2) small molecule antagonists, cell-based qHTS assay
Source: 824
External Id: ADRB2713

Total 207, Current Page 1 of 21

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

N,N'-dibromo-5,5-dimethyl hydantoin

1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione

DIBROMANTIN

3-DibroMo-5

DDH

1,3-dibromo-5,5-dimethyl-hydantoin

1,3-Dibromo-5,5-dimethyl-2,4-imidazolidinedione

1,3-Dibromo-5,5-dimethyl hydantoin

EINECS 201-030-9

1,3-Dibromo-5,5-dimethylhydantoin

Bromotoin

dibromantine

BROMTOIN

DIBROMATIN

1,3-Dibromo-5

DBDMH

1,3-dibromo-4,4-dimethyl-2,5-dioxoimidazolidine

MFCD00003189

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of 1,3-Dibromo-5,5-dimethylhydantoin?

A: CAS number of 1,3-Dibromo-5,5-dimethylhydantoin is 77-48-5.

Q: What are the upstream materials of 1,3-Dibromo-5,5-dimethylhydantoin?

A: Related upstream materials(CAS) of 1,3-Dibromo-5,5-dimethylhydantoin: 77-71-4;118-52-5;143-33-9;67-64-1.

Q: What is the LogP of 1,3-Dibromo-5,5-dimethylhydantoin?

A: LogP of 1,3-Dibromo-5,5-dimethylhydantoin is 1.68.

Q: What is the polar surface area (PSA) of 1,3-Dibromo-5,5-dimethylhydantoin?

A: Polar surface area (PSA) of 1,3-Dibromo-5,5-dimethylhydantoin is 40.62000.

Q: What is the melting point of 1,3-Dibromo-5,5-dimethylhydantoin?

A: Melting point of 1,3-Dibromo-5,5-dimethylhydantoin is 197-199 °C (dec.)(lit.).

Q: What are the uses of 1,3-Dibromo-5,5-dimethylhydantoin?

A: Main uses of 1,3-Dibromo-5,5-dimethylhydantoin: 1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Q: What is the boiling point of 1,3-Dibromo-5,5-dimethylhydantoin?

A: Boiling point of 1,3-Dibromo-5,5-dimethylhydantoin is 250.2±23.0 °C at 760 mmHg.

Q: What is the molecular weight of 1,3-Dibromo-5,5-dimethylhydantoin?

A: Molecular weight of 1,3-Dibromo-5,5-dimethylhydantoin is 285.921.

Q: What is the SMILES notation of 1,3-Dibromo-5,5-dimethylhydantoin?

A: SMILES notation of 1,3-Dibromo-5,5-dimethylhydantoin is CC1(C)C(=O)N(Br)C(=O)N1Br.

Q: What is the molecular formula of 1,3-Dibromo-5,5-dimethylhydantoin?

A: Molecular formula of 1,3-Dibromo-5,5-dimethylhydantoin is C5H6Br2N2O2.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1,3-Dibromo-5,5-dimethylhydantoin
Price: Check
Purity: 97.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3-Dibromo-5,5-dimethylhydantoin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 77-48-5 1,3-Dibromo-5,5-dimethylhydantoin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 1,3-Dibromo-5,5-dimethylhydantoin
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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1,3-Dibromo-5,5-dimethylhydantoin

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