Bisantrene

Suppliers

Names

[ Name ]:
Bisantrene

[Synonym ]:
9,10-Anthracenedicarbaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
MFCD01743164
9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone)
Zantrene
ADAH
BISANTRENE HCL
anthracene-9,10-dicarbaldehyde bis-imidazolidin-2-ylidenehydrazone
Orange Crush

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Boiling Point ]:
646.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₂N₈

[ Molecular Weight ]:
398.46400

[ Flash Point ]:
344.7ºC

[ Exact Mass ]:
398.19700

[ PSA ]:
97.56000

[ LogP ]:
2.06900

[ Index of Refraction ]:
1.757

[ Water Solubility ]:
deionized water: soluble8mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CA9645000

CHEMICAL NAME :: 9,10-Anthracenedicarboxaldehyde, bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-

CAS REGISTRY NUMBER :: 78186-34-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H22-N8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,2703,1986

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ Hazard Codes ]:
Xn;N

[ Risk Phrases ]:
R22;R50/53

[ Safety Phrases ]:
S60;S61

[ RIDADR ]:
UN 2811 6.1/PG 3

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

In vitro effects of bisantrene on fresh clonogenic leukemia cells: a preliminary study on 15 cases.

Haematologica 75(6) , 527-31, (1990)

In vitro clonogenic assays may be useful for determining the sensitivity of leukemic cells to chemotherapeutic agents. We evaluated the antileukemic effect of Bisantrene (an anthracene derivative now ...

Phase II trial of Bisantrene for metastatic melanoma: an Illinois cancer council study.

Med. Pediatr. Oncol. 19(2) , 126-8, (1991)

Sixteen patients with metastatic melanoma entered this phase II study of the efficacy of monthly cycles of Bisantrene. Toxicity was characterized by leukopenia, resulting in the hospitalization of one...

Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity.

Clin. Cancer Res. 2(6) , 973-80, (1996)

In this work, we demonstrate a protective effect conferred by the human multidrug resistance gene (MDR1) to populations of the murine hematopoietic system against the toxic effects of bisantrene, a no...