1, 2-Didemethylcolchicine

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Names

[ CAS No. ]:
78231-83-1

[ Name ]:
1, 2-Didemethylcolchicine

[Synonym ]:
Acetamide,N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-,(S)
1,2-Didemethylcolchicine
Acetamide,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)
1,2-O-didemethylcolchicine

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
783.5ºC at 760 mmHg

[ Molecular Formula ]:
C20H21NO6

[ Molecular Weight ]:
371.38400

[ Flash Point ]:
427.6ºC

[ Exact Mass ]:
371.13700

[ PSA ]:
105.09000

[ LogP ]:
2.65650

[ Index of Refraction ]:
1.642

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8585500
CHEMICAL NAME :
Acetamide, N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9- oxobenzo(a)heptalen-7 -yl)-, (S)-
CAS REGISTRY NUMBER :
78231-83-1
LAST UPDATED :
198912
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H21-N-O6
MOLECULAR WEIGHT :
371.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
167 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-demethylcolchicine
  • Colchicine

DownStream

  • Acetamide, N-(6,7,8,10-tetrahydro-4,11-dimethoxy-10-oxoheptaleno(1,2-e)-1,3-benzodioxol-8-yl)-, (S)-

Related Compounds

  • 1,2-Diacetyl-1,2-didemethylcolchicine
  • 1-(2-Bromoethoxy)-1,1,2,2,2-pentafluoroethane
  • 1-(2-Aminophenyl)-2-imidazolidinone
  • 1,2-bis(1,3-benzothiazol-2-yl)ethane-1,2-dione
  • 1,2-Oxathiane, 2-oxide
  • [1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]methanol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • 1-Ethynylcyclobutan-1-amine hydrochloride