1, 2-Didemethylcolchicine

Modify Date: 2025-08-25 18:53:39

1, 2-Didemethylcolchicine structure	Common Name	1, 2-Didemethylcolchicine
	CAS Number	78231-83-1	Molecular Weight	371.38400
	Density	1.38g/cm3	Boiling Point	783.5ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₁NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	427.6ºC

Name	N-(1,2-dihydroxy-3,10-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
Synonym	More Synonyms

Density	1.38g/cm3
Boiling Point	783.5ºC at 760 mmHg
Molecular Formula	C₂₀H₂₁NO₆
Molecular Weight	371.38400
Flash Point	427.6ºC
Exact Mass	371.13700
PSA	105.09000
LogP	2.65650
Index of Refraction	1.642
InChIKey	QCOIAAVYXNEUDX-UHFFFAOYSA-N
SMILES	COc1cc2c(c(O)c1O)-c1ccc(OC)c(=O)cc1C(NC(C)=O)CC2

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8585500

CHEMICAL NAME :: Acetamide, N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9- oxobenzo(a)heptalen-7 -yl)-, (S)-

CAS REGISTRY NUMBER :: 78231-83-1

LAST UPDATED :: 198912

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N-O6

MOLECULAR WEIGHT :: 371.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 167 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

~25%

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

Colchicine

CAS#:64-86-8

~27%

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

Acetamide,N-[(7...

CAS#:57866-21-4

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260

Colchicine

CAS#:64-86-8

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

Colchicine

CAS#:64-86-8

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

Precursor 2
CAS#:7336-36-9 2-DEMETHYLCOLCHICINE CAS#:64-86-8 Colchicine
DownStream 1
CAS#:78249-43-1 Acetamide, N-(6...

Acetamide,N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-,(S)

1,2-Didemethylcolchicine

Acetamide,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)

1,2-O-didemethylcolchicine

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1, 2-Didemethylcolchicine

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.