1, 2-Didemethylcolchicine

Modify Date: 2025-08-25 18:53:39

1, 2-Didemethylcolchicine Structure
1, 2-Didemethylcolchicine structure
 Common Name 1, 2-Didemethylcolchicine
CAS Number 78231-83-1 Molecular Weight 371.38400
Density 1.38g/cm3 Boiling Point 783.5ºC at 760 mmHg
Molecular Formula C20H21NO6 Melting Point N/A
MSDS N/A Flash Point 427.6ºC

 Names

Name N-(1,2-dihydroxy-3,10-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.38g/cm3
Boiling Point 783.5ºC at 760 mmHg
Molecular Formula C20H21NO6
Molecular Weight 371.38400
Flash Point 427.6ºC
Exact Mass 371.13700
PSA 105.09000
LogP 2.65650
Index of Refraction 1.642
InChIKey QCOIAAVYXNEUDX-UHFFFAOYSA-N
SMILES COc1cc2c(c(O)c1O)-c1ccc(OC)c(=O)cc1C(NC(C)=O)CC2

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8585500
CHEMICAL NAME :
Acetamide, N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9- oxobenzo(a)heptalen-7 -yl)-, (S)-
CAS REGISTRY NUMBER :
78231-83-1
LAST UPDATED :
198912
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H21-N-O6
MOLECULAR WEIGHT :
371.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
167 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

 Synthetic Route

2-demethylcolchicine structure

2-demethylcolchicine

CAS#:7336-36-9

~25%

1, 2-Didemethylcolchicine Structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372
Colchicine structure

Colchicine

CAS#:64-86-8

~27%

2-demethylcolchicine structure

2-demethylcolchicine

CAS#:7336-36-9

Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]- structure

Acetamide,N-[(7...

CAS#:57866-21-4

1, 2-Didemethylcolchicine Structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260
Colchicine structure

Colchicine

CAS#:64-86-8

~%

2-demethylcolchicine structure

2-demethylcolchicine

CAS#:7336-36-9

1, 2-Didemethylcolchicine Structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688
Colchicine structure

Colchicine

CAS#:64-86-8

~%

1, 2-Didemethylcolchicine Structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

 Synonyms

Acetamide,N-(5,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-,(S)
1,2-Didemethylcolchicine
Acetamide,6,7,9-tetrahydro-1,2-dihydroxy-3,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)
1,2-O-didemethylcolchicine
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