(S)-1,1,1-TRIFLUORO-N-(PYRROLIDIN-2-YLMETHYL)METHANESULFONAMIDE

Names

[ Name ]:
(S)-1,1,1-TRIFLUORO-N-(PYRROLIDIN-2-YLMETHYL)METHANESULFONAMIDE

[Synonym ]:
(S)-1,1,1-Trifluoro-N-(pyrrolidin-2-ylmethyl)methanesulfonamide
N-[(2S)-2-PYRROLIDINYLMETHYL]-TRIFLUOROMETHANESULFONAMIDE

Chemical & Physical Properties

[ Melting Point ]:
205-215°C

[ Molecular Formula ]:
C₆H₁₁F₃N₂O₂S

[ Molecular Weight ]:
232.22400

[ Exact Mass ]:
232.04900

[ PSA ]:
66.58000

[ LogP ]:
1.97810

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
34

[ Safety Phrases ]:
26-36/37/39-45

[ RIDADR ]:
UN 3263 8/PG 3

[ Hazard Class ]:
8.0

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

A recyclable fluorous (S)-pyrrolidine sulfonamide promoted direct, highly enantioselective Michael addition of ketones and aldehydes to nitroolefins in water.

Org. Lett. 8 , 3077-3079, (2006)

[reaction: see text] A recycle and reusable fluorous (S)-pyrrolidine sulfonamide organocatalyst has been developed for promoting highly enantio- and diastereoselective Michael addition reactions of ke...

Highly enantioselective aldol reactions catalyzed by a recyclable fluorous (S) pyrrolidine sulfonamide on water.

Org. Lett. 10 , 1211-1214, (2008)

Fluorous (S) pyrrolidine sulfonamide serves as an efficient promoter for highly enantioselective aldol reactions of ketones and aldehydes with aromatic aldehydes on water. A notable feature of the org...

Direct, highly enantioselective pyrrolidine sulfonamide catalyzed Michael addition of aldehydes to nitrostyrenes.

Angew. Chem. Int. Ed. Engl. 44 , 1369-1371, (2005)

5-Methyl-6-methylidene-3-oxo-2-[(phenanthridin-6-yl)methyl]-1,2,3,6-tetrahydropyridazine-4-carbonitrile
1-{3',5',6',7'-Tetrahydrospiro[cyclobutane-1,4'-imidazo[4,5-c]pyridin]-5'-yl}prop-2-en-1-one
rac-(2R,5R)-1-[4-(fluorosulfonyl)-1H-pyrrole-2-carbonyl]-5-methylpyrrolidine-2-carboxylic acid
5-[2-(2-Tert-butylpyrimidin-5-yl)ethenyl]pyrazine-2-carbonitrile
N-({2,4-dioxo-1,3-diazaspiro[4.4]nonan-6-yl}methyl)prop-2-enamide
N-{[4-(aminomethyl)-2-fluorophenyl]methyl}-1-(oxan-2-yl)cyclobutane-1-carboxamide hydrochloride
N-{1-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]ethyl}prop-2-enamide
N-{4-methyl-3-[(propan-2-yl)carbamoyl]phenyl}-4-phenyl-1-(prop-2-enoyl)piperidine-4-carboxamide
N-{[2-(2,3-dimethylphenoxy)pyridin-4-yl]methyl}-1-(prop-2-enoyl)piperidine-4-carboxamide
N-(2-ethoxy-5-methylpyridin-3-yl)-1-(prop-2-enoyl)piperidine-4-carboxamide

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