Ameltolide

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Names

[ CAS No. ]:
787-93-9

[ Name ]:
Ameltolide

[Synonym ]:
4-Amino-2',6'-benzoxylidide
Ameltolide

Chemical & Physical Properties

[ Density]:
1.182g/cm3

[ Boiling Point ]:
340.8ºC at 760 mmHg

[ Molecular Formula ]:
C15H16N2O

[ Molecular Weight ]:
240.30000

[ Flash Point ]:
159.9ºC

[ Exact Mass ]:
240.12600

[ PSA ]:
55.12000

[ LogP ]:
3.79210

[ Index of Refraction ]:
1.656

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DM5325000
CHEMICAL NAME :
2',6'-Benzoxylidide, 4-amino-
CAS REGISTRY NUMBER :
787-93-9
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H16-N2-O
MOLECULAR WEIGHT :
240.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
161 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959- Volume(issue)/page/year: 29,198,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
4095 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Liver - changes in liver weight Related to Chronic Data - death
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 19,197,1992 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1300 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,37,1991

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-(2,6-dimethylphenyl)-4-nitrobenzamide
  • 2,6-xylidine
  • 4-aminobenzoyl chloride
  • 4-Nitrobenzoyl chloride

DownStream

  • N-(2,6-dimethylphenyl)-4-hydroxybenzamide

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 2-chloro-N-(1,1-dioxo-1lambda6-thiolan-3-yl)pyridine-3-carboxamide hydrochloride
  • N-(1-cyanocyclohexyl)-2-(3-fluoro-4-nitrophenoxy)-N-methylacetamide
  • [(6-Chloropyridazin-3-yl)methyl][1-(dimethylamino)-1-phenylpropan-2-yl]amine
  • 1-(1,3-Dioxaindane-5-carbonyl)-4-(prop-2-yn-1-yl)-1,4-diazepane
  • 1-[1-(4-Chlorophenyl)cyclopropanecarbonyl]-4-(prop-2-yn-1-yl)-1,4-diazepane
  • 2-[5-(2-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1-[4-(prop-2-yn-1-yl)-1,4-diazepan-1-yl]ethan-1-one
  • 3-[2-(Tert-butoxy)phenyl]-1-[(5-chloropyrazin-2-yl)methyl]urea
  • 6-bromo-N-ethyl-N-(3,3,3-trifluoro-2-hydroxypropyl)imidazo[1,2-a]pyrazine-3-carboxamide
  • N-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-6-yl}prop-2-enamide
  • 6-Chloro-2-(piperidin-4-yl)-1,8-naphthyridine dihydrochloride
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