2-Chloroacetamide

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
256.0±13.0 °C at 760 mmHg

[ Melting Point ]:
116-118 °C(lit.)

[ Molecular Formula ]:
C₂H₄ClNO

[ Molecular Weight ]:
93.512

[ Flash Point ]:
108.6±19.8 °C

[ Exact Mass ]:
92.998138

[ PSA ]:
43.09000

[ LogP ]:
-0.85

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.448

Click to get detail MSDS

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB5075000

CHEMICAL NAME :: Acetamide, 2-chloro-

CAS REGISTRY NUMBER :: 79-07-2

BEILSTEIN REFERENCE NO. :: 0878191

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C2-H4-Cl-N-O

MOLECULAR WEIGHT :: 93.52

WISWESSER LINE NOTATION :: ZV1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 155 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 960 mg/kg/30D-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Cardiac - EKG changes not diagnostic of specified effects Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 210,255,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1156 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 90 (estimated)

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H317-H361f

[ Precautionary Statements ]:
P201-P280-P301 + P310 + P330-P308 + P313-P333 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R43;R62

[ Safety Phrases ]:
S22-S36/37-S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
AB5075000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29241900

Click to get detail synthetic route

Precursor

Chloroacetyl chloride
Chloroacetic anhydride
methyl chloroacetate
glycolamide
N-chloro-alpha-chloroacetamide
Water
N-methyl-1,2-diphenyl-ethanamine
1,3-Diaminopropane
2-chloroacetonitrile

DownStream

2-[(2-methyl-5-nitro-1H-imidazol-4-yl)sulfanyl]acetamide
ACETAMIDE, 2-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO)-
(phenylsulfonyl)acetamide
3,4-dihydroquinoxalin-2-ol
2-(benzylamino)acetamide
N-(1-adamantyl)-2-chloroacetamide
6-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE
Glycine, N-2-propen-1-yl-
2-Piperazinone
2-PHENYL-5-OXAZOLONE

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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