Chloroacetic acid

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Names

[ CAS No. ]:
79-11-8

[ Name ]:
Chloroacetic acid

[Synonym ]:
Acetic acid,chloro
Monochloroethanoic acid
Acide chloracetique
2 chloroacetate
2-chloro acetic acid
Monochloressigsaeure
Chloracetic acid
Chloroethanoic acid
EINECS 201-178-4
MFCD00002683
chloroacetic acid
Chloroacetic acid,solid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
189.0±0.0 °C at 760 mmHg

[ Melting Point ]:
61 °C

[ Molecular Formula ]:
C₂H₃ClO₂

[ Molecular Weight ]:
94.497

[ Flash Point ]:
71.5±19.8 °C

[ Exact Mass ]:
93.982155

[ PSA ]:
37.30000

[ LogP ]:
-0.05

[ Vapour density ]:
3.26 (vs air)

[ Vapour Pressure ]:
0.3±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.438

[ Stability ]:
Stable. Deliquescent. Incompatible with strong bases, alkalies, most common metals, strong oxidizing agents.

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AF8575000

CHEMICAL NAME :: Acetic acid, chloro-

CAS REGISTRY NUMBER :: 79-11-8

BEILSTEIN REFERENCE NO. :: 0605438

LAST UPDATED :: 199710

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C2-H3-Cl-O2

MOLECULAR WEIGHT :: 94.50

WISWESSER LINE NOTATION :: QV1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9750 mg/kg/13W-I

TOXIC EFFECTS :: Cardiac - other changes Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20800 ug/m3/17W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 gm/kg/13W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3840 mg/kg/16D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20800 ug/m3/17W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg/65W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 160 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** TOXICOLOGY REVIEW APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 11,13,1955 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.3 ppm;STEL 1 ppm;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18070 No. of Facilities: 1196 (estimated) No. of Industries: 9 No. of Occupations: 14 No. of Employees: 4726 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 18070 No. of Facilities: 265 (estimated) No. of Industries: 12 No. of Occupations: 20 No. of Employees: 10912 (estimated) No. of Female Employees: 1723 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H315

[ Precautionary Statements ]:
P210-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R34;R50

[ Safety Phrases ]:
S23-S37-S45-S61-S36-S26-S16

[ RIDADR ]:
UN 1751 6.1/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
AF8575000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29154000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

methyl 3,3,3-trifluoro-2-hydroxy-2-trifluoromethylpropionate
Eugenol
Chloroacetyl chloride
acetic acid
Dichloroacetic acid
N-Benzyl-2-chloroacetamide
2-Chloroethanol
Trichloroethylene
Glycolic acid

DownStream

2-(4-methyl-2-propan-2-ylphenoxy)acetic acid
BIS[2-(2-CHLOROACETOXY)ETHYL] ETHER
2-chloro-N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]acetamide
Acetic acid 1-acetyl-5-chloro-1H-indol-3-yl ester
2-Amino-5-chlorobenzophenone
2-chloro-6-(chloromethyl)-13-phenyl-12H-benzo[d][1,3,7]benzotriazonine
2,8-DICHLORO-6,12-DIPHENYLDIBENZO(B,F)(1,5)DIAZOCINE
Acetic acid, 2-chloro-,1,1'-(1,4-phenylene) ester
Acetic acid,2-arsonoyl-
3-propan-2-yl-2-sulfanylidene-1,3-thiazolidin-4-one

Customs

[ HS Code ]: 29154000

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