Pempidine

Names

[ CAS No. ]:
79-55-0

[ Name ]:
Pempidine

[Synonym ]:
PIPERIDINE,1,2,2,6,6-PENTAMETHYL
Pyrilene
MFCD00006493
N-methyl-2,2,6,6-tetramethylpiperidine
Perolysen
EINECS 201-211-2
M+B 4486
Pempidine
N,2,2,6,6-pentamethyl piperidine

Chemical & Physical Properties

[ Density]:
0.858 g/mL at 25 °C(lit.)

[ Boiling Point ]:
187-188 °C(lit.)

[ Melting Point ]:
137-141ºC

[ Molecular Formula ]:
C₁₀H₂₁N

[ Molecular Weight ]:
155.28000

[ Flash Point ]:
122 °F

[ Exact Mass ]:
155.16700

[ PSA ]:
3.24000

[ LogP ]:
2.59720

[ Index of Refraction ]:
n20/D 1.460(lit.)

[ Storage condition ]:
Flammables area

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN2190000

CHEMICAL NAME :: Piperidine, 1,2,2,6,6-pentamethyl-

CAS REGISTRY NUMBER :: 79-55-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H21-N

MOLECULAR WEIGHT :: 155.32

WISWESSER LINE NOTATION :: T6NTJ A1 B1 B1 F1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

Safety Information

[ Symbol ]:

GHS02, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R10

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
UN 1992 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
TN2190000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,2,2,6,6-pentamethylpiperidine 1-oxide
2,2,6,6-tetramethylpiperidine-1-carbaldehyde
2,2,6,6-Tetramethylpiperidine
Formaldehyde
methyl iodide
Methyl p-toluenesulfonate
methyl phenyl sulfoxide

DownStream

α-Cumyl alcohol
2,2,6,6-Tetramethylpiperidine
2,2,6,6-tetramethyl-1-oxidopiperidin-1-ium
2,2,6,6-tetramethylpiperidine-1-carbaldehyde
2-METHYL-3-PHENYL-1H-INDEN-1-ONE
3,5-Di-Tert-Butylbenzyl Alcohol
butyl 3-phenylprop-2-ynoate
Benzyl alcohol

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.

Neurochem. Res. 21(9) , 1141-8, (1996)

The modulation of [3H]ACh release by nicotinic compounds was studied in superfused rat hippocampal synaptosomes loaded with [3H]choline, (-)-Nicotine (0.1-10 microM) evoked a dose-dependent increase i...

Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission.

Brain Res. 444(1) , 189-94, (1988)

Both presynaptic and postsynaptic blockade of ganglionic transmission during the period of naturally occurring ganglion cell death reduced the number of surviving neurons in the sympathetic ganglia (S...

Understanding channel blocking in the nicotinic acetylcholine receptor.

Receptors Channels 7(4) , 273-88, (2001)

Ion-channel blockers are molecules that obstruct the path used by ions to cross the membrane through a protein channel. Many of these are local anesthetics, toxins or drugs of abuse, and the knowledge...