Pempidine
Pempidine structure
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Common Name | Pempidine | ||
|---|---|---|---|---|
| CAS Number | 79-55-0 | Molecular Weight | 155.28000 | |
| Density | 0.858 g/mL at 25 °C(lit.) | Boiling Point | 187-188 °C(lit.) | |
| Molecular Formula | C10H21N | Melting Point | 137-141ºC | |
| MSDS | Chinese USA | Flash Point | 122 °F | |
| Symbol |
GHS02, GHS06 |
Signal Word | Danger | |
Use of PempidinePempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension. |
Summary: 1,2,2,6,6-pentamethylpiperidine (Pempidine) is a colorless to light yellow transparent liquid with CAS number 79-55-0, molecular formula C10H21N, and molecular weight 155.28000. Its melting point is 137-141°C and boiling point is 187-188°C. This compound is used to treat hypertension as a nerve ganglion blocking drug. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 1,2,2,6,6-pentamethylpiperidine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Pempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension. |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 0.858 g/mL at 25 °C(lit.) |
|---|---|
| Boiling Point | 187-188 °C(lit.) |
| Melting Point | 137-141ºC |
| Molecular Formula | C10H21N |
| Molecular Weight | 155.28000 |
| Flash Point | 122 °F |
| Exact Mass | 155.16700 |
| PSA | 3.24000 |
| LogP | 2.59720 |
| Index of Refraction | n20/D 1.460(lit.) |
| InChIKey | XULIXFLCVXWHRF-UHFFFAOYSA-N |
| SMILES | CN1C(C)(C)CCCC1(C)C |
| Storage condition | Flammables area |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS02, GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H226-H301-H315-H319-H335 |
| Precautionary Statements | P261-P301 + P310-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R10 |
| Safety Phrases | S26-S36/37 |
| RIDADR | UN 1992 3/PG 3 |
| WGK Germany | 3 |
| RTECS | TN2190000 |
| Packaging Group | III |
| Hazard Class | 3 |
| HS Code | 2933399090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~75%
Pempidine CAS#:79-55-0 |
| Literature: Caliskan, Hafize; Zaim, Oemer Synthetic Communications, 2010 , vol. 40, # 20 p. 3078 - 3083 |
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~80%
Pempidine CAS#:79-55-0 |
| Literature: Rae, Ian D.; Woolcock, Mark L. Australian Journal of Chemistry, 1990 , vol. 43, # 2 p. 447 - 450 |
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~31%
Pempidine CAS#:79-55-0 |
| Literature: Kostyanovskii, R. G.; Shakhgel'diev, M. A.; Nabiev, O. G. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 12 p. 2593 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 12 p. 2826 - 2827 |
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~%
Pempidine CAS#:79-55-0 |
| Literature: US4208525 A1, ; |
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~%
Pempidine CAS#:79-55-0 |
| Literature: Journal of the American Chemical Society, , vol. 79, p. 5279,5286 |
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~%
Pempidine CAS#:79-55-0 |
| Literature: Journal of the American Chemical Society, , vol. 79, p. 5439 |
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~%
Pempidine CAS#:79-55-0 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 42 p. 17384 - 17387 |
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~%
Pempidine CAS#:79-55-0 |
| Literature: Bulletin of the Chemical Society of Japan, , vol. 68, # 5 p. 1401 - 1408 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 9 | |
CAS#:617-94-7
CAS#:220418-56-4
CAS#:5132-07-0
CAS#:13304-52-4
CAS#:77387-57-6
CAS#:80220-93-5
CAS#:100-51-6This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.
Neurochem. Res. 21(9) , 1141-8, (1996) The modulation of [3H]ACh release by nicotinic compounds was studied in superfused rat hippocampal synaptosomes loaded with [3H]choline, (-)-Nicotine (0.1-10 microM) evoked a dose-dependent increase i... |
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Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission.
Brain Res. 444(1) , 189-94, (1988) Both presynaptic and postsynaptic blockade of ganglionic transmission during the period of naturally occurring ganglion cell death reduced the number of surviving neurons in the sympathetic ganglia (S... |
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Understanding channel blocking in the nicotinic acetylcholine receptor.
Receptors Channels 7(4) , 273-88, (2001) Ion-channel blockers are molecules that obstruct the path used by ions to cross the membrane through a protein channel. Many of these are local anesthetics, toxins or drugs of abuse, and the knowledge... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| PIPERIDINE,1,2,2,6,6-PENTAMETHYL |
| Pyrilene |
| MFCD00006493 |
| N-methyl-2,2,6,6-tetramethylpiperidine |
| Perolysen |
| EINECS 201-211-2 |
| M+B 4486 |
| Pempidine |
| N,2,2,6,6-pentamethyl piperidine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of 1,2,2,6,6-pentamethylpiperidine? |
| A: SMILES notation of 1,2,2,6,6-pentamethylpiperidine is CN1C(C)(C)CCCC1(C)C. |
| Q: What are the uses of 1,2,2,6,6-pentamethylpiperidine? |
| A: Main uses of 1,2,2,6,6-pentamethylpiperidine: Pempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension. |
| Q: What is the LogP of 1,2,2,6,6-pentamethylpiperidine? |
| A: LogP of 1,2,2,6,6-pentamethylpiperidine is 2.59720. |
| Q: What is the molecular weight of 1,2,2,6,6-pentamethylpiperidine? |
| A: Molecular weight of 1,2,2,6,6-pentamethylpiperidine is 155.28000. |
| Q: What is the InChIKey of 1,2,2,6,6-pentamethylpiperidine? |
| A: InChIKey of 1,2,2,6,6-pentamethylpiperidine is XULIXFLCVXWHRF-UHFFFAOYSA-N. |
| Q: What is the CAS number of 1,2,2,6,6-pentamethylpiperidine? |
| A: CAS number of 1,2,2,6,6-pentamethylpiperidine is 79-55-0. |
| Q: What is the melting point of 1,2,2,6,6-pentamethylpiperidine? |
| A: Melting point of 1,2,2,6,6-pentamethylpiperidine is 137-141ºC. |
| Q: What is the English name of 1,2,2,6,6-pentamethylpiperidine? |
| A: The English name of 1,2,2,6,6-pentamethylpiperidine is 1,2,2,6,6-pentamethylpiperidine. |
| Q: What are the storage conditions for 1,2,2,6,6-pentamethylpiperidine? |
| A: Storage conditions for 1,2,2,6,6-pentamethylpiperidine: Flammables area. |
| Q: What is the molecular formula of 1,2,2,6,6-pentamethylpiperidine? |
| A: Molecular formula of 1,2,2,6,6-pentamethylpiperidine is C10H21N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |