Pempidine

Modify Date: 2024-01-02 17:28:20

Pempidine Structure
Pempidine structure
Common Name Pempidine
CAS Number 79-55-0 Molecular Weight 155.28000
Density 0.858 g/mL at 25 °C(lit.) Boiling Point 187-188 °C(lit.)
Molecular Formula C10H21N Melting Point 137-141ºC
MSDS Chinese USA Flash Point 122 °F
Symbol GHS02 GHS06
GHS02, GHS06
Signal Word Danger

 Use of Pempidine


Pempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension.

 Names

Name 1,2,2,6,6-pentamethylpiperidine
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.858 g/mL at 25 °C(lit.)
Boiling Point 187-188 °C(lit.)
Melting Point 137-141ºC
Molecular Formula C10H21N
Molecular Weight 155.28000
Flash Point 122 °F
Exact Mass 155.16700
PSA 3.24000
LogP 2.59720
Index of Refraction n20/D 1.460(lit.)
Storage condition Flammables area

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TN2190000
CHEMICAL NAME :
Piperidine, 1,2,2,6,6-pentamethyl-
CAS REGISTRY NUMBER :
79-55-0
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H21-N
MOLECULAR WEIGHT :
155.32
WISWESSER LINE NOTATION :
T6NTJ A1 B1 B1 F1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

 Safety Information

Symbol GHS02 GHS06
GHS02, GHS06
Signal Word Danger
Hazard Statements H226-H301-H315-H319-H335
Precautionary Statements P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn: Harmful;
Risk Phrases R10
Safety Phrases S26-S36/37
RIDADR UN 1992 3/PG 3
WGK Germany 3
RTECS TN2190000
Packaging Group III
Hazard Class 3
HS Code 2933399090

 Synthetic Route

~75%

Pempidine Structure

Pempidine

CAS#:79-55-0

Literature: Caliskan, Hafize; Zaim, Oemer Synthetic Communications, 2010 , vol. 40, # 20 p. 3078 - 3083

~80%

Pempidine Structure

Pempidine

CAS#:79-55-0

Literature: Rae, Ian D.; Woolcock, Mark L. Australian Journal of Chemistry, 1990 , vol. 43, # 2 p. 447 - 450

~31%

Pempidine Structure

Pempidine

CAS#:79-55-0

Literature: Kostyanovskii, R. G.; Shakhgel'diev, M. A.; Nabiev, O. G. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 12 p. 2593 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 12 p. 2826 - 2827

~%

Pempidine Structure

Pempidine

CAS#:79-55-0

Literature: US4208525 A1, ;

~%

Pempidine Structure

Pempidine

CAS#:79-55-0

Literature: Journal of the American Chemical Society, , vol. 79, p. 5279,5286

~%

Pempidine Structure

Pempidine

CAS#:79-55-0

Literature: Journal of the American Chemical Society, , vol. 79, p. 5439

~%

Pempidine Structure

Pempidine

CAS#:79-55-0

Literature: Journal of the American Chemical Society, , vol. 134, # 42 p. 17384 - 17387

~%

Pempidine Structure

Pempidine

CAS#:79-55-0

Literature: Bulletin of the Chemical Society of Japan, , vol. 68, # 5 p. 1401 - 1408

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles28

More Articles
Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.

Neurochem. Res. 21(9) , 1141-8, (1996)

The modulation of [3H]ACh release by nicotinic compounds was studied in superfused rat hippocampal synaptosomes loaded with [3H]choline, (-)-Nicotine (0.1-10 microM) evoked a dose-dependent increase i...

Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission.

Brain Res. 444(1) , 189-94, (1988)

Both presynaptic and postsynaptic blockade of ganglionic transmission during the period of naturally occurring ganglion cell death reduced the number of surviving neurons in the sympathetic ganglia (S...

Understanding channel blocking in the nicotinic acetylcholine receptor.

Receptors Channels 7(4) , 273-88, (2001)

Ion-channel blockers are molecules that obstruct the path used by ions to cross the membrane through a protein channel. Many of these are local anesthetics, toxins or drugs of abuse, and the knowledge...

 Synonyms

PIPERIDINE,1,2,2,6,6-PENTAMETHYL
Pyrilene
MFCD00006493
N-methyl-2,2,6,6-tetramethylpiperidine
Perolysen
EINECS 201-211-2
M+B 4486
Pempidine
N,2,2,6,6-pentamethyl piperidine
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