Ethyl α-hydroxyisobutyrate

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Names

[ CAS No. ]:
80-55-7

[ Name ]:
Ethyl α-hydroxyisobutyrate

[Synonym ]:
Propanoic acid, 2-hydroxy-2-methyl-, ethyl ester (9CI)
Ethyl α-hydroxyisobutyrate
Ethyl 2-hydroxy-2-methylpropanoate
EINECS 201-290-3
Propanoic acid, 2-hydroxy-2-methyl-, ethyl ester
MFCD00004458

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
152.1±8.0 °C at 760 mmHg

[ Molecular Formula ]:
C6H12O3

[ Molecular Weight ]:
132.158

[ Flash Point ]:
44.4±0.0 °C

[ Exact Mass ]:
132.078644

[ PSA ]:
46.53000

[ LogP ]:
0.16

[ Vapour Pressure ]:
1.3±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.428

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OD5672000
CHEMICAL NAME :
Lactic acid, 2-methyl-, ethyl ester
CAS REGISTRY NUMBER :
80-55-7
BEILSTEIN REFERENCE NO. :
0878308
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C6-H12-O3
MOLECULAR WEIGHT :
132.18
WISWESSER LINE NOTATION :
QX1&1&VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,189,1942 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7053 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 919 (estimated) No. of Female Employees: 306 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R36/38

[ Safety Phrases ]:
S26-S36-S16

[ RIDADR ]:
UN 3272 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
OD5672000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
29181980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 2-(methoxymethoxy)-2-methylpropanoate
  • Ethyl 2-bromoisobutyrate
  • Formaldehyde
  • Ethanol
  • 2-Hydroxyisobutyric acid
  • H-Aib-Oet.HCl
  • 2-methyl-2-(10-methyl-9,10-dihydro-acridin-9-yl)-propionic acid methyl ester
  • Acetone cyanohydrin
  • Diethyloxalate
  • Ethyl iodide

DownStream

  • 2-methylheptane-2,3-diol
  • Ethyl 2-fluoro-2-methylpropanoate
  • Ethyl methacrylate
  • 2-METHYL-2-(5-(TRIFLUOROMETHYL)PYRIDIN-2-YLOXY)PROPANOIC ACID
  • (2R)-2-Methylpentanedioic acid
  • ethyl 2-methoxy-2-methylpropanoate
  • Ethyl 2-methyl-2-phenoxypropanoate
  • phenyl acetate
  • Methacrylic acid
  • 2-Hydroxyisobutyric acid

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds

  • methyl α-hydroxyisobutyrate-d6
  • ethyl α-phenylthiocarbamylglyoxalate p-methylphenylhydrazone
  • ethyl α-phenylthiocarbamylglyoxalate p-methoxyphenylhydrazone
  • ethyl α-(hydroxyimino)-β-<2-(methylthio)indol-3-yl>propanoate
  • ethyl α-methylthio-2,4-dimethylphenylacetate
  • Ethyl-α-carbethoxy-4-dimethylamino-2-nitrocinnamate
  • (1R)-1-(4-Methylphenyl)ethane-1,2-diamine
  • [(2-Bromo-1-phenylethoxy)methyl]benzene
  • 2,5-Dichloro-3-[3-(3,5-dichloro-phenyl)-ureido]-benzoic acid
  • 5-Bromo-2-[3-(3,5-dimethyl-phenyl)-ureido]-benzoic acid
  • 5-(3-ethenylphenyl)-1H-1,2,3,4-tetrazole
  • N-Methyl-N-[(4-nitrophenyl)sulfonyl]acetamide
  • tert-butyl N-(3-hydroxyphenyl)-N-(2-methylpropyl)carbamate
  • 2-Amino-3-butylphenol
  • 6-Cyclopentyl-5-methyl-nicotinic acid isopropyl ester
  • 2-bromo-N,N-dimethyl-5-nitrobenzamide
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