Lathosterol

Suppliers

Names

[ CAS No. ]:
80-99-9

[ Name ]:
Lathosterol

[Synonym ]:
Cholest-7-en-3beta-ol
Cholest-7-en-3-ol
5alpha-Cholest-7-en-3beta-ol
(3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
5alpha-cholest-7-en-3beta-ol
7-cholestenol
Lathosterol

Chemical & Physical Properties

[ Density]:
0.98 g/cm3

[ Boiling Point ]:
479.4ºC

[ Molecular Formula ]:
C27H46O

[ Molecular Weight ]:
386.65400

[ Flash Point ]:
208.9ºC

[ Exact Mass ]:
386.35500

[ PSA ]:
20.23000

[ LogP ]:
7.38870

[ Index of Refraction ]:
1.525

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FZ7000000
CHEMICAL NAME :
5-alpha-Cholest-7-en-3-beta-ol
CAS REGISTRY NUMBER :
80-99-9
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C27-H46-O
MOLECULAR WEIGHT :
386.73
WISWESSER LINE NOTATION :
L E5 B666 IUTJ A1 E1 FY1&3Y1&1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 19,977,1957

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
FZ7000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (3β)-7-Dehydro Cholesterol
  • Cholest-5-ene-3β,7β-diol dibenzoate
  • 5α-cholest-7-ene-3β-ol acetate
  • cholesterol
  • acetic acid-(7α-hydroxy-5α-cholestanyl-(3β)-ester)
  • 7-Oxo Cholesterol 3-Acetate
  • lathosterone
  • Ethanol
  • Aluminium isopropoxide

DownStream

  • 10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Articles

Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(32) , 3806-11, (2011)

Phytosterols (PS; β-sitosterol and campesterol) and cholesterol precursors (CP; desmosterol and lathosterol) have been suggested as important biochemical markers of cholesterol intestinal absorption a...

Serum lipid responses to weight loss differ between overweight adults with familial hypercholesterolemia and those with familial combined hyperlipidemia.

J. Nutr. 144(8) , 1219-26, (2014)

The effect of weight loss on lipids differs among individuals, although whether it can modify the management of hereditary hyperlipidemias has not yet been explored. The objective of this study was to...

Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients

Atherosclerosis 225(2) , 388-96, (2012)

Objective Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates sy...


More Articles

Related Compounds

  • lathosterol
  • lathosterol-d7
  • Lathosterol TMS
  • (S)-Lathosterol-d4
  • lathosterol oxidase
  • Lathosterolamide MGI-39
  • 4-(1-Methylcyclopropyl)pyrimidin-5-amine
  • Tert-butyl 3-(aminooxymethyl)-3-fluoroazetidine-1-carboxylate
  • tert-Butyl 4-hydroxy-2-azabicyclo[2.1.1]hexane-2-carboxylate
  • methyl 6-amino-1-(oxan-2-yl)-1H-indazole-3-carboxylate
  • 2-Methyl-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxylic acid
  • 2-[1-(9H-Fluoren-9-ylmethoxycarbonyl)piperidin-4-yl]-2-fluoroacetic acid
  • N-(3-Iodo-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide hydrochloride
  • methyl 7-hydroxy-1-(oxan-2-yl)-1H-indazole-3-carboxylate
  • N'-[2-(4-Fluorophenyl)ethyl]-1-phenylethane-1,2-diamine;dihydrochloride
  • 1-[(2R,5S)-2,5-Dimethylpiperazin-1-YL]prop-2-EN-1-one 2,2,2-trifluoroacetic acid
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