Roxithromycin

Suppliers

Names

[ CAS No. ]:
80214-83-1

[ Name ]:
Roxithromycin

[Synonym ]:
Roxid
Overal
Forilin
MFCD00214389
Roxithromycin
Claramid
biaxsig
RU 965
Assoral
roxyithromycin
Brilid
(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2-methoxyethoxy)methoxy]imino}-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
Rulid
Surlid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
864.7±75.0 °C at 760 mmHg

[ Melting Point ]:
115- 120ºC

[ Molecular Formula ]:
C41H76N2O15

[ Molecular Weight ]:
837.047

[ Flash Point ]:
476.7±37.1 °C

[ Exact Mass ]:
836.524597

[ PSA ]:
216.89000

[ LogP ]:
3.73

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.535

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KF4990000
CHEMICAL NAME :
Erythromycin, 9-O-((2-methoxyethoxy)methyl)oxime
CAS REGISTRY NUMBER :
80214-83-1
LAST UPDATED :
199806
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C41-H76-N2-O15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
830 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 36(Suppl 4),94,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
665 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
.2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1471,1995

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
KF4990000

[ HS Code ]:
2941500000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(Chloromethoxy)-2-methoxyethane
  • Erythromycin A Oxime

DownStream

Customs

[ HS Code ]: 2941500000

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Related Compounds

  • Roxithromycin
  • (Z)-roxithromycin
  • N-DEMETHYLROXITHROMYCIN
  • Decladinoseroxithromycin
  • 2'-O-[(2-Methoxyethoxy)Methyl] RoxithroMycin
  • 1-(3,4-Dimethoxyphenyl)-3-[2-(4-phenylpiperazin-1-yl)ethyl]urea
  • 1-[2-(4-Phenylpiperazin-1-yl)ethyl]-3-[2-(trifluoromethyl)phenyl]urea
  • 1-(2-Amino-3-bromo-5-methoxyphenyl)ethan-1-one
  • 4-Ethynyl-N,N-bis(1-methylethyl)benzenemethanamine
  • 2-(6-Methoxy-1,2,3,4-tetrahydroquinolin-1-yl)-1-[4-(2-phenylethenesulfonyl)piperazin-1-yl]ethan-1-one
  • 4,4-Diethyl-6-iodo-1,4-dihydrobenzo[d][1,3]oxazin-2-one
  • I(3)-(Trifluoromethyl)benzenebutanoic acid
  • 1-(2-Methylphenyl)pyrazol-3-amine
  • 1-(Butan-2-yl)-3-iodobicyclo[1.1.1]pentane
  • 7-Iodoisochroman
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