Simethicone

Suppliers

Names

[ CAS No. ]:
8050-81-5

[ Name ]:
Simethicone

[Synonym ]:
4-trimethylsilylstyrene
poly(3-hexylthiophene)
poly(4-trimethylsilylstyrene)
Simethicone
p-(Trimethylsilyl)styrene
trimethyl-(4-vinyl-phenyl)-silane
3-(Hex-1-yl)thiophene
poly(acrylamide)
3-hexyltiophene

Chemical & Physical Properties

[ Density]:
1 g/mL at 20ºC

[ Boiling Point ]:
96.5ºC at 760 mmHg

[ Molecular Formula ]:
C6H18O4Si3

[ Molecular Weight ]:
238.46100

[ Flash Point ]:
6.3ºC

[ Exact Mass ]:
238.05100

[ PSA ]:
52.60000

[ LogP ]:
1.56770

[ Appearance of Characters ]:
emulsion | Colorless

[ Vapour Pressure ]:
5 mm Hg ( 20 °C)

[ Index of Refraction ]:
n20/D 1.406

[ Storage condition ]:
room temp

[ Water Solubility ]:
Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VW6200000
CHEMICAL NAME :
Simethicone
CAS REGISTRY NUMBER :
8050-81-5
LAST UPDATED :
199504

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
AMSGAO AMA Archives of Surgery. (Chicago, IL) V.61-80, 1950-60. For publisher information, see ARSUAX. Volume(issue)/page/year: 78,220,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
REFERENCE :
AMSGAO AMA Archives of Surgery. (Chicago, IL) V.61-80, 1950-60. For publisher information, see ARSUAX. Volume(issue)/page/year: 78,220,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4515 No. of Facilities: 1163 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 90654 (estimated) No. of Female Employees: 75193 (estimated)

Safety Information

[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;

[ Risk Phrases ]:
36/37-20

[ Safety Phrases ]:
26-36-23

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TQ2690000

Articles

The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea.

Aliment. Pharmacol. Ther. 36(1) , 64-73, (2012)

Loperamide (LOP) is an anti-diarrhoeal agent which is thought to act largely by slowing transit with an uncertain effect on the fluid content of the small and large bowel in humans. Adding simethicone...

Commentary: low-volume bowel preparation for colonoscopy - authors' reply.

Aliment. Pharmacol. Ther. 36(10) , 989, (2012)

Commentary: low-volume bowel preparation for colonoscopy.

Aliment. Pharmacol. Ther. 36(10) , 988-9, (2012)


More Articles

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  • 4-(Difluoromethyl)-6-iodo-3-methoxy-2-(trifluoromethoxy)pyridine
  • 4-(Difluoromethyl)-6-fluoro-3-methylpicolinic acid
  • 4-Amino-5-(difluoromethyl)-2-iodonicotinoyl chloride
  • 4-Bromo-5-(difluoromethyl)-3-nitropyridin-2-ol
  • 2-bromo-N-((5-(furan-2-yl)pyridin-3-yl)methyl)benzenesulfonamide
  • Tert-butyl 3-(5-bromo-4-methylpyridin-2-yl)oxy-2,2-dimethylpropanoate
  • 2-(2,3,5-Trichlorophenyl)pyridine-4-acetic acid
  • 2-(2,3-Dichlorophenyl)-3-(trifluoromethyl)pyridine-4-methanol
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