Simethicone
Simethicone structure
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Common Name | Simethicone | ||
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| CAS Number | 8050-81-5 | Molecular Weight | 238.46100 | |
| Density | 1 g/mL at 20ºC | Boiling Point | 96.5ºC at 760 mmHg | |
| Molecular Formula | C6H18O4Si3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 6.3ºC | |
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The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea.
Aliment. Pharmacol. Ther. 36(1) , 64-73, (2012) Loperamide (LOP) is an anti-diarrhoeal agent which is thought to act largely by slowing transit with an uncertain effect on the fluid content of the small and large bowel in humans. Adding simethicone (SIM) to LOP improves its efficacy, but the mechanism of i... |
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Commentary: low-volume bowel preparation for colonoscopy - authors' reply.
Aliment. Pharmacol. Ther. 36(10) , 989, (2012)
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Commentary: low-volume bowel preparation for colonoscopy.
Aliment. Pharmacol. Ther. 36(10) , 988-9, (2012)
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Randomised clinical trial: low-volume bowel preparation for colonoscopy - a comparison between two different PEG-based formulations.
Aliment. Pharmacol. Ther. 36(8) , 717-24, (2012) Low-volume bowel preparations with polyethylene glycol (PEG) have been shown to provide an equivalent cleansing with improved tolerability as compared with standard PEG bowel preparation for colonoscopy. A new iso-osmotic sulphate-free formulation of PEG-Citr... |
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A new low-volume isosmotic polyethylene glycol solution plus bisacodyl versus split-dose 4 L polyethylene glycol for bowel cleansing prior to colonoscopy: a randomised controlled trial.
Dig. Liver Dis. 45(1) , 23-7, (2013) 4-L polyethylene glycol preparations are effective for colon cleansing before colonoscopy. However, large volume and unpleasant taste reduce tolerability and acceptability limiting patient compliance. A new isosmotic low-volume polyethylene glycol preparation... |
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Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association.
J. Pharm. Pharmacol. 65(4) , 567-73, (2013) Alverine, an antispasmodic agent for the treatment of irritable bowel syndrome (IBS), may be combined with simethicone, a protective agent of the mucosa. Stress is a major factor triggering abdominal pain in IBS and causing hypersensitivity to colonic distens... |
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Size exclusion chromatography with evaporative light scattering detection as a method for speciation analysis of polydimethylsiloxanes. III. Identification and determination of dimeticone and simeticone in pharmaceutical formulations.
J. Pharm. Biomed. Anal. 58 , 200-7, (2012) The pharmaceutical industry is one of the more important sectors for the use of polydimethylsiloxanes (PDMS), which belong to the organosilicon polymers. In drugs for internal use, they are used as an active pharmaceutical ingredient (API) called dimeticone o... |
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Improvements in soft gelatin capsule sample preparation for USP-based simethicone FTIR analysis.
J. Pharm. Biomed. Anal. 74 , 223-6, (2013) Due to the absence of a significant chromophore, Simethicone raw material and finished product analysis is achieved using a FTIR-based method that quantifies the polydimethylsiloxane (PDMS) component of the active ingredient. The method can be found in the US... |
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Premedication with N-acetylcysteine and simethicone improves mucosal visualization during gastroscopy: a randomized, controlled, endoscopist-blinded study.
Eur. J. Gastroenterol. Hepatol. 25(7) , 778-83, (2013) Diagnostic gastroscopy provides a unique opportunity to diagnose early oesophagogastric neoplasia; however, intraluminal mucus and bile can obscure mucosal visualization. The aim of this study was to determine whether the use of a premedication solution conta... |
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[Comparison of a new medical device with domperidone in functional dyspepsia: a randomized, cross-over, controlled study].
Minerva Med. 102(2) , 133-9, (2011) Management of functional dyspepsia is still controversial. Different controlled trials reported a superiority of prokinetics, H2-receptor antagonists and proton-pump inhibitors over placebo; nevertheless, symptomatic improvement after therapy is often incompl... |