Colistin methanesulfonate sodium salt

Suppliers

Names

[ Name ]:
Colistin methanesulfonate sodium salt

[Synonym ]:
Colistrimethate sodium
EINECS 232-516-9
MFCD00130824
Colimycin M
Colistimethate sodium
Sodium colistimethate
Colistin sodium methanesulfonate
Colistimethate
Sodium methanesulfonate - N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-({(6S,9R,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl}amino)-2-butanyl]amino}-3-hydroxy-1-oxo-2-butanyl]amino}-1-oxo-2-butanyl]-6-methyloctanamide (5:5:1)

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₈H₁₁₅N₁₆Na₅O₂₈S₅

[ Molecular Weight ]:
1759.898

[ Exact Mass ]:
1758.615845

[ Appearance of Characters ]:
white to faintly beige

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble10mg/mL

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
3249

[ WGK Germany ]:
2

[ RTECS ]:
GH1650000

Articles

High-throughput hydrophilic interaction chromatography coupled to tandem mass spectrometry for the optimized quantification of the anti-Gram-negatives antibiotic colistin A/B and its pro-drug colistimethate.

J. Chromatogr. A. 1369 , 52-63, (2014)

Colistin is a last resort's antibacterial treatment in critically ill patients with multi-drug resistant Gram-negative infections. As appropriate colistin exposure is the key for maximizing efficacy w...

Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium.

PLoS ONE 10 , e0142097, (2015)

Exacerbations associated with chronic lung infection with Pseudomonas aeruginosa are a major contributor to morbidity, mortality and premature death in cystic fibrosis. Such exacerbations are treated ...

In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

Antimicrob. Agents Chemother. 45 , 781-785, (2001)

The in vitro pharmacodynamic properties of colistin and colistin methanesulfonate were investigated by studying the MICs, time-kill kinetics, and postantibiotic effect (PAE) against mucoid and nonmuco...

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