Colistin methanesulfonate sodium salt
Colistin methanesulfonate sodium salt structure
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Common Name | Colistin methanesulfonate sodium salt | ||
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| CAS Number | 8068-28-8 | Molecular Weight | 1759.898 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C58H115N16Na5O28S5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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High-throughput hydrophilic interaction chromatography coupled to tandem mass spectrometry for the optimized quantification of the anti-Gram-negatives antibiotic colistin A/B and its pro-drug colistimethate.
J. Chromatogr. A. 1369 , 52-63, (2014) Colistin is a last resort's antibacterial treatment in critically ill patients with multi-drug resistant Gram-negative infections. As appropriate colistin exposure is the key for maximizing efficacy while minimizing toxicity, individualized dosing optimizatio... |
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Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium.
PLoS ONE 10 , e0142097, (2015) Exacerbations associated with chronic lung infection with Pseudomonas aeruginosa are a major contributor to morbidity, mortality and premature death in cystic fibrosis. Such exacerbations are treated with antibiotics, which generally lead to an improvement in... |
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In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Antimicrob. Agents Chemother. 45 , 781-785, (2001) The in vitro pharmacodynamic properties of colistin and colistin methanesulfonate were investigated by studying the MICs, time-kill kinetics, and postantibiotic effect (PAE) against mucoid and nonmucoid strains of Pseudomonas aeruginosa isolated from patients... |
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Computational fluid dynamics (CFD) assisted performance evaluation of the Twincer™ disposable high-dose dry powder inhaler.
J. Pharm. Pharmacol. 64(9) , 1316-25, (2012) To use computational fluid dynamics (CFD) for evaluating and understanding the performance of the high-dose disposable Twincer™ dry powder inhaler, as well as to learn the effect of design modifications on dose entrainment, powder dispersion and retention beh... |
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High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study.
Clin. Infect. Dis. 54(12) , 1720-6, (2012) Gram-negative bacteria susceptible only to colistin (COS) are emerging causes of severe nosocomial infections, reviving interest in the use of colistin. However, consensus on the most effective way to administer colistin has not yet been reached.All patients ... |
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Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: a randomised study.
Thorax 68(4) , 344-50, (2013) To assess efficacy and safety of a new dry powder formulation of inhaled colistimethate sodium in patients with cystic fibrosis (CF) aged ≥6 years with chronic Pseudomonas aeruginosa lung infection.A prospective, centrally randomised, phase III, open-label st... |
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Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers.
Clin. Pharmacol. Ther. 89(6) , 875-9, (2011) Colistin pharmacokinetics (PK) was investigated in young healthy volunteers after a 1-h infusion of 80 mg (1 million international units (MIU)) of the prodrug colistin methanesulfonate (CMS). Concentration levels of CMS and colistin were determined in plasma ... |
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Combined intravenous and intraventricular administration of colistin methanesulfonate in critically ill patients with central nervous system infection.
Antimicrob. Agents Chemother. 57(4) , 1938-40, (2013) Colistin pharmacokinetics were prospectively studied after intravenous administration of colistin methanesulphonate in critically ill patients without central nervous system infection (controls, n = 5) and in patients with external ventricular drain-associate... |
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Colistin pharmacokinetics in intensive care unit patients on continuous venovenous haemodiafiltration: an observational study.
J. Antimicrob. Chemother. 67(10) , 2459-62, (2012) Available data on colistin pharmacokinetics in patients undergoing continuous renal replacement therapy (CRRT) are limited. Our aim was to study colistin pharmacokinetics in critically ill patients treated with colistin methane sulphonate for Gram-negative se... |
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Interaction of colistin and colistin methanesulfonate with liposomes: colloidal aspects and implications for formulation.
J. Pharm. Sci. 101(9) , 3347-59, (2012) Interaction of colistin and colistin methanesulfonate (CMS) with liposomes has been studied with the view to understanding the limitations to the use of liposomes as a more effective delivery system for pulmonary inhalation of this important class of antibiot... |