Aceclidine

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Names

[ CAS No. ]:
827-61-2

[ Name ]:
Aceclidine

[Synonym ]:
3-Acetoxyquinuclidine
Quinuclidin-3-yl acetate
aceclidine
Glaucostat

Chemical & Physical Properties

[ Boiling Point ]:
221.5ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₅NO₂

[ Molecular Weight ]:
169.22100

[ Flash Point ]:
85ºC

[ Exact Mass ]:
169.11000

[ PSA ]:
29.54000

[ LogP ]:
0.58160

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD6195000

CHEMICAL NAME :: 3-Quinuclidinol, acetate (ester)

CAS REGISTRY NUMBER :: 827-61-2

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H15-N-O2

MOLECULAR WEIGHT :: 169.25

WISWESSER LINE NOTATION :: T66 A B CNTJ AOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 189,295,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,320,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 35,55,1972

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Ethanoic anhydride
3-Quinuclidinol
3-Quinuclidinone hydrochloride
3-acetoxy-1-((methacryloyloxy)methyl)quinuclidin-1-ium chloride

DownStream

(R)-(-)-3-Quinuclidinol
1-Azoniabicyclo[2.2.2]octane,3-(acetyloxy)-1-(phenylmethyl)-, bromide (1:1)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Aceclidine
aceclidine
ACECLIDINE SALICYLATE
Aceclidine hydrochloride
5-Acetamido-1,2-oxazole-4-carboxylic acid
tert-butyl 2-oxo-3-(pyrrolidin-3-yl)-hexahydro-2H-pyrrolo[3,4-d][1,3]oxazole-5-carboxylate
1-ethyl-3-(pyrrolidin-3-yloxy)-1H-pyrazole
2-Oxo-5-(piperidin-3-yl)piperidine-4-carboxylic acid
2-Hydroxy-5-(5-methylpyrimidin-2-yl)pyridine-4-carboxylic acid
5-Amino-3-bromo-1-(2-methanesulfinylethyl)-4-methyl-1,2-dihydropyridin-2-one
2-Bromo-5-(3-oxomorpholin-4-yl)benzonitrile
3,5-Dibromo-2-(3-oxomorpholin-4-yl)benzaldehyde
methyl 5-amino-4-(2-methoxyethyl)-1-(oxan-4-yl)-1H-pyrazole-3-carboxylate
4,4-Difluoro-1-(1-methylcyclopropyl)pentane-1,3-dione

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