2-Hydroxy-1,4-naphoquinone

Suppliers

Names

[ CAS No. ]:
83-72-7

[ Name ]:
2-Hydroxy-1,4-naphoquinone

[Synonym ]:
C.I. Natural Orange 6
MFCD00001678
2-Hydroxy-1,4-naphthochinone
2-Hydroxy-1,4-naphoquinone
EINECS 201-496-3
2-Hydroxy-1,4-naphthoquinone
hydroxynaphthoquinone
Natural Orange 6
1,4-Naphthalenedione, 2-hydroxy-
2-Hydroxy-p-naphthoquinone
2-hydroxynaphthalene-1,4-dione
hennotannic acid
lawsone
2-Hydroxy-1,4-napthoquinone

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
339.9±42.0 °C at 760 mmHg

[ Melting Point ]:
192-195 °C (dec.)(lit.)

[ Molecular Formula ]:
C10H6O3

[ Molecular Weight ]:
174.153

[ Flash Point ]:
173.6±24.4 °C

[ Exact Mass ]:
174.031693

[ PSA ]:
54.37000

[ LogP ]:
1.55

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.681

[ Water Solubility ]:
2 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QL8200000
CHEMICAL NAME :
1,4-Naphthoquinone, 2-hydroxy-
CAS REGISTRY NUMBER :
83-72-7
BEILSTEIN REFERENCE NO. :
1565260
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H6-O3
MOLECULAR WEIGHT :
174.16
WISWESSER LINE NOTATION :
L66 BV EVJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
522 mg/kg/6D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,61,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9568 No. of Facilities: 227 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2271 (estimated) No. of Female Employees: 1817 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36;R68

[ Safety Phrases ]:
S26-S37/39-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QL8200000

[ Packaging Group ]:
II

[ HS Code ]:
2914690090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Naphthoresorcinol
  • 2-Hydroxy-3-iodo-1,4-naphthoquinone
  • benzocatechol
  • 1,2,4-Naphthalenetriol,1,2,4-triacetate
  • naphthalene-1,2,4-triol
  • 2-Methoxynaphthalene
  • BENZOHYDROQUINONE
  • 1,4-Naphthalenedione,2-chloro-3-hydroxy-
  • 1,4-naphthoquinone

DownStream

  • 3-(2-ethylbut-1-enyl)-4-hydroxynaphthalene-1,2-dione
  • 3-hept-1-enyl-4-hydroxynaphthalene-1,2-dione
  • 1,3-INDANDIONE
  • bi-lawsone
  • 2-Hydroxy-3-iodo-1,4-naphthoquinone
  • 2,2,2-trifluoroethyl tosylate
  • Beta-Lapachone
  • alpha-Lapachone
  • Deschloro Atovaquone
  • 1,4-Naphthalenedione,2-[3-[4-(acetyloxy)phenyl]propyl]-3-hydroxy-

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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Related Compounds

  • 2-hydroxy-1-(4-methylpiperidin-1-yl)ethanone
  • 2-hydroxy-1,4-benzoquinone
  • 2-HYDROXY-1-(4-(METHYLSULFONYL)PHENYL)ETHANONE
  • 2-hydroxy-1-(4-methoxyquinolin-2-yl)-2-(4-methoxy-1H-quinolin-2-ylidene)ethanone
  • 2-hydroxy-1-(4-methoxyphenyl)-2-pyridin-4-ylethanone
  • 2-hydroxy-1-(4-hydroxyphenyl)propan-1-one
  • N-(4-acetamidophenyl)-6-(4-fluorophenyl)imidazo[2,1-b]thiazole-3-carboxamide
  • N-(5-acetamido-2-methoxyphenyl)-6-(4-fluorophenyl)imidazo[2,1-b]thiazole-3-carboxamide
  • N-(2-(2,4-dimethylphenyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-(4-methoxyphenoxy)acetamide
  • N-benzyl-6-(4-methoxyphenyl)imidazo[2,1-b]thiazole-3-carboxamide
  • N-(2-fluorophenyl)-6-(4-methoxyphenyl)imidazo[2,1-b]thiazole-3-carboxamide
  • N-(2,4-difluorophenyl)-6-(4-methoxyphenyl)imidazo[2,1-b]thiazole-3-carboxamide
  • N-(3-methoxyphenyl)-6-(4-methoxyphenyl)imidazo[2,1-b]thiazole-3-carboxamide
  • N-(4-acetylphenyl)-6-(4-methoxyphenyl)imidazo[2,1-b]thiazole-3-carboxamide
  • Methyl 2-(6-(4-methoxyphenyl)imidazo[2,1-b]thiazole-3-carboxamido)benzoate
  • N-(2-ethylphenyl)-6-(4-methoxyphenyl)imidazo[2,1-b]thiazole-3-carboxamide
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