1-Methyl-7-chloro-5-benzoylhydrazino-2,3-dihydro-1H-1,4-benzodiazepin- 2-one

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Names

[ CAS No. ]:
84044-26-8

[ Name ]:
1-Methyl-7-chloro-5-benzoylhydrazino-2,3-dihydro-1H-1,4-benzodiazepin- 2-one

[Synonym ]:
1-Methyl-7-chloro-5-phenyl-3-benzoylhydrazino-2,3-dihydro-1H-1,4-benzodiazepin-2-one
1-Methyl-7-chloro-5-phenyl-3-acetylhydrazino-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
628ºC at 760 mmHg

[ Molecular Formula ]:
C17H15ClN4O2

[ Molecular Weight ]:
342.78000

[ Flash Point ]:
333.6ºC

[ Exact Mass ]:
342.08800

[ PSA ]:
73.80000

[ LogP ]:
2.28000

[ Index of Refraction ]:
1.665

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG5105000
CHEMICAL NAME :
Benzoic acid, 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1, 4-benzodiazepin-3-yl) hydrazide
CAS REGISTRY NUMBER :
84044-26-8
LAST UPDATED :
199803
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H19-Cl-N4-O2
MOLECULAR WEIGHT :
418.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 16,617,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzohydrazide
  • 3,7-dichloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

DownStream

Related Compounds

  • 3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methoxybutanamido]propanoic acid
  • 2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methoxy-N-(2,2,2-trifluoroethyl)butanamido]acetic acid
  • rac-(3R,4R)-1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methoxybutanoyl]-4-methylpyrrolidine-3-carboxylic acid
  • 5-(4-Tert-butylcyclohexyl)-2-ethyl-1,3,2lambda5-dioxaphosphinane-2-thione
  • 5-{1,4-Dioxaspiro[4.5]decan-8-yl}-2-ethyl-1,3,2lambda5-dioxaphosphinane-2-thione
  • Tert-butyl 3-cyano-3-fluoroazepane-1-carboxylate
  • Tert-butyl (2R,4S)-2-(2-aminoethyl)-4-fluoropyrrolidine-1-carboxylate
  • 5-(3,5-Dimethylcyclohexyl)-2-ethyl-1,3,2lambda5-dioxaphosphinane-2-thione
  • 3-(2-Ethyl-2-sulfanylidene-1,3,2lambda5-dioxaphosphinan-5-yl)-8lambda6-thiabicyclo[3.2.1]octane-8,8-dione
  • 5-(1-Cyclopropylpiperidin-4-yl)-1,3,2lambda6-dioxathiane-2,2-dione
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