1-Methyl-7-chloro-5-benzoylhydrazino-2,3-dihydro-1H-1,4-benzodiazepin- 2-one

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Names

[ CAS No. ]:
84044-26-8

[ Name ]:
1-Methyl-7-chloro-5-benzoylhydrazino-2,3-dihydro-1H-1,4-benzodiazepin- 2-one

[Synonym ]:
1-Methyl-7-chloro-5-phenyl-3-benzoylhydrazino-2,3-dihydro-1H-1,4-benzodiazepin-2-one
1-Methyl-7-chloro-5-phenyl-3-acetylhydrazino-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
628ºC at 760 mmHg

[ Molecular Formula ]:
C17H15ClN4O2

[ Molecular Weight ]:
342.78000

[ Flash Point ]:
333.6ºC

[ Exact Mass ]:
342.08800

[ PSA ]:
73.80000

[ LogP ]:
2.28000

[ Index of Refraction ]:
1.665

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG5105000
CHEMICAL NAME :
Benzoic acid, 2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1, 4-benzodiazepin-3-yl) hydrazide
CAS REGISTRY NUMBER :
84044-26-8
LAST UPDATED :
199803
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H19-Cl-N4-O2
MOLECULAR WEIGHT :
418.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 16,617,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzohydrazide
  • 3,7-dichloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

DownStream

Related Compounds

  • (4-Bromophenyl)(4-(6-methylpyridazin-3-yl)piperazin-1-yl)methanone
  • 2-Ethynyl-4-(trifluoromethyl)benzonitrile
  • 1,5-Dibromo-3-methyl-2-(trifluoromethyl)benzene
  • 4-bromo-2-(1H-imidazol-4-yl)phenol
  • Ethyl 2-(4-acetamidocyclohexylidene)acetate
  • 2-(6-Aminobenzo[d]isoxazol-3-yl)isoindoline-1,3-dione
  • 2,4-Dichloro-5-methyl-7-tosyl-7h-pyrrolo[2,3-d]pyrimidine
  • N,N-Dimethyl-2-[[3-methyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]benzenesulfonamide
  • 6,6a(2)-Thiobis[3,4-dihydro-3-phenyl-2H-1,3-benzoxazine]
  • (S)-2-[6-(Dimethylamino)-2-benzothiazolyl]-4,5-dihydrothiazole-4-carboxylic Acid
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