7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine

Names

[ Name ]:
7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine

[Synonym ]:
7-methyl-6,8-dimethylthio-pyrrolo<1,2-a>pyrazine
MIII
Mbmtpp
6,8-dimethylthio-7-methylpyrrolo <1,2-a> pyrazine
Metabolite III

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Molecular Formula ]:
C₁₀H₁₂N₂S₂

[ Molecular Weight ]:
224.34600

[ Exact Mass ]:
224.04400

[ PSA ]:
67.90000

[ LogP ]:
3.08650

[ Index of Refraction ]:
1.656

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

methyl iodide
Oltipraz
8-mercapto-7-methylpyrrolo[1,2-a]pyrazine-6(2H)-thione
Sodium ethanethiolate

DownStream

Articles

Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1.

Clin. Pharmacol. Ther. 88(3) , 360-8, (2010)

Oltipraz is a potential candidate drug for the treatment of liver fibrosis (LF) and liver cirrhosis (LC). The pharmacokinetics of oltipraz and its major rearranged metabolite (7-methyl-6,8-bis(methylt...

Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz.

Mol. Pharmacol. 48(1) , 15-20, (1995)

Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication in vitro (ED50 approximately 10 microM), undergoes extensive metabolism in vivo. Most of the orally administered drug undergoe...

2,3-DIHYDRO-6,8-DIMETHYL-4H-1-BENZOTHIOPYRAN-4-ONE
7-methyl-6 (or 8-)-methylthio-pyrrolo(1,2-a)pyrazine disulphide
6-(ethyldisulfanyl)-7-methyl-8-(methylthio)pyrrolo[1,2-a]pyrazine
7-methyl-8-sulfanyl-2H-pyrrolo[1,2-a]pyrazine-6-thione
(7S,8aS)-7-amino-2-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione(SALTDATA: FREE)
cyclo(prolyl-N-methylphenylalanyl)
3-(Hydroxymethyl)-2,4-diiodophenol
3-(Difluoromethyl)-4-iodo-6-(trifluoromethoxy)pyridin-2-amine
2-Bromo-6-(trifluoromethyl)benzylamine hydrochloride
2-Chloro-5-(difluoromethyl)-6-(trifluoromethoxy)pyridin-3-ol
2-Bromo-6-(difluoromethoxy)-4-nitropyridine
6-Amino-5-(difluoromethyl)-4-nitropicolinamide
4-(1-Isocyanatocyclopropyl)benzonitrile
6-(Difluoromethyl)-5-(hydroxymethyl)-3-(trifluoromethoxy)picolinonitrile
1-(Difluoromethyl)-2,3-dimethyl-5-nitrobenzene
2-Cyano-4-(difluoromethyl)-3-(hydroxymethyl)benzoic acid

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