7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine
7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine structure
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Common Name | 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine | ||
|---|---|---|---|---|
| CAS Number | 84201-40-1 | Molecular Weight | 224.34600 | |
| Density | 1.25g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H12N2S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1.
Clin. Pharmacol. Ther. 88(3) , 360-8, (2010) Oltipraz is a potential candidate drug for the treatment of liver fibrosis (LF) and liver cirrhosis (LC). The pharmacokinetics of oltipraz and its major rearranged metabolite (7-methyl-6,8-bis(methylthio)H-pyrrolo[1,2-a]pyrazine (RM)) were evaluated after sin... |
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Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz.
Mol. Pharmacol. 48(1) , 15-20, (1995) Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication in vitro (ED50 approximately 10 microM), undergoes extensive metabolism in vivo. Most of the orally administered drug undergoes opening of the dithiolethione ring, reduction, recyclizat... |
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