(2,6-Difluorophenyl)acetic acid

Names

[ Name ]:
(2,6-Difluorophenyl)acetic acid

[Synonym ]:
2,6-Difluorobenzeneacetic acid
EINECS 285-289-3
QV1R BF FF
2-(2,6-difluorophenyl)acetic acid
(2,6-Difluorophenyl)acetic acid
Benzeneacetic acid, 2,6-difluoro-
MFCD00010001

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
251.6±25.0 °C at 760 mmHg

[ Melting Point ]:
100-102 °C(lit.)

[ Molecular Formula ]:
C₈H₆F₂O₂

[ Molecular Weight ]:
172.129

[ Flash Point ]:
106.0±23.2 °C

[ Exact Mass ]:
172.033585

[ PSA ]:
37.30000

[ LogP ]:
1.65

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.508

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29163900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,2,3-Trifluorobenzene
Ethyl cyanoacetate

DownStream

Methyl 2-(3-Amino-2,6-Difluorophenyl)Acetate
2,6-Difluorobenzaldehyde
2-(2,6-difluoro-3-nitrophenyl)acetic acid
methyl 2-(2,6-difluoro-3-nitrophenyl)acetate
2-(2,6-Difluorophenyl)propanoic acid

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Design and synthesis of Rho kinase inhibitors (II).

Bioorg. Med. Chem. 15 , 350-364, (2007)

In a previous study, we identified several structurally unrelated scaffolds of the Rho kinase inhibitor using pharmacophore information obtained from the results of a high-throughput screening and str...

Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency.

Bioorg. Med. Chem. Lett. 23(4) , 1110-3, (2013)

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved activity towards Tyr181Cys containing variants was pursued with the assistance of free energy perturbation (FEP) calcul...

2-amino-2-(2,6-difluorophenyl)acetic acid
(2,6-difluorophenyl)acetic acid ethyl ester
(2,6-difluorophenyl)acetic acid methyl ester
2-Amino-2-(2,6-difluorophenyl)acetic acid hydrochloride
(4-Bromo-2,6-difluorophenyl)acetic acid
2-(4-amino-2,6-difluorophenyl)acetic acid
3'-benzyl-1-methyl-1'H-spiro[indole-3,2'-quinazoline]-2,4'(1H,3'H)-dione
N-((1-(thiophen-3-ylmethyl)piperidin-4-yl)methyl)naphthalene-1-sulfonamide
2-cyclohexyl-N-[4-methoxy-3-(1H-tetrazol-1-yl)phenyl]acetamide
N~2~-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)acetyl]-N-(2-phenylethyl)glycinamide
4-methyl-2-[(3-methylbutyl)amino]-N-(pyridin-2-ylmethyl)-1,3-thiazole-5-carboxamide
2-[acetyl(isopentyl)amino]-N-cyclopentyl-4-methyl-1,3-thiazole-5-carboxamide
1-[4-(morpholin-4-ylsulfonyl)phenyl]-5-oxo-N-(1,3-thiazol-2-yl)pyrrolidine-3-carboxamide
1-isopropyl-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,5,6,7-tetrahydrocyclopenta[b]pyrazolo[4,3-e]pyridine-4-carboxamide
3-(5-chloro-2-methoxyphenyl)-4-oxo-N-(1,3-thiazol-2-yl)-3,4-dihydroquinazoline-7-carboxamide
[4-(3-Chlorophenyl)piperazin-1-yl][4-(4-methoxyphenyl)-1,2,3-thiadiazol-5-yl]methanone

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