1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-((1R)-(6-METHOXYQUINOLIN-4-YL)((2R,4S,5R)-5-VINYLQUINUCLIDIN-2-YL)METHYL)THIOUREA

Suppliers

Names

[ CAS No. ]:
852913-25-8

[ Name ]:
1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-((1R)-(6-METHOXYQUINOLIN-4-YL)((2R,4S,5R)-5-VINYLQUINUCLIDIN-2-YL)METHYL)THIOUREA

[Synonym ]:
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(R)-(6-methoxyquinolin-4-yl)-(8-vinylquinuclidin-2-yl)methyl]thiourea
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROPANOL-1 MIN.
1-[3,5-bis(trifluoromethyl)phenyl]-1-propanol
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROPANOL-1

Chemical & Physical Properties

[ Melting Point ]:
150°C

[ Molecular Formula ]:
C29H28F6N4OS

[ Molecular Weight ]:
594.61400

[ Exact Mass ]:
594.18900

[ PSA ]:
81.51000

[ LogP ]:
7.60690

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 9-Amino(9-deoxy)epi-quinidinetrihydrochloride
  • 3,5-di(trifluoromethyl)phenyl isothiocyanate
  • Quinidine
  • 4-[(R)-azido[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]methyl]-6-methoxyquinoline

DownStream

Articles

Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance.

Angew. Chem. Int. Ed. Engl. 44 , 6367-6370, (2005)

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Org. Lett. 7 , 1967-1969, (2005)

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.


More Articles

Related Compounds

  • Methyl N-2-methyl-butyl-4-nitropyrrole-2-carboxylate
  • 1-Chloro-3-cyclohexyl-2-fluorobenzene
  • N-(4-Aminophenyl)-4-(isopentyloxy)benzamide
  • [3-(Morpholin-4-yl)propyl](pentan-3-yl)amine
  • 1-(3-Bromopropoxy)-3-fluorobenzene
  • 3-(3,4-diethoxybenzamido)-N-(4-ethoxyphenyl)benzofuran-2-carboxamide
  • 3'-Amino[1,1'-biphenyl]-2-carboxamide
  • 1-Phenyl-3-methylcyclobutanecarbonitrile
  • 1-(Thiophen-3-yl)cyclobutane-1-carbonitrile
  • (E)-N-methyl-N-[(3-methyl-1-benzothiophen-2-yl)methyl]-3-(2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)prop-2-enamide
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.