Mirtazapine

Suppliers

Names

[ Name ]:
Mirtazapine

[Synonym ]:
Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-
Zispin
(14bR)-2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO[2.1-A]PYRIDO[2.3-C][2]BENZAZEPINE
Mirtazapin
1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO[2,1-A]PYRIDO[2,3-C][2]BENZAZEPINE
Remeron
ORG-3770
UNII:A051Q2099Q
2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
MIRTAZEPINE
2-Methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine
Mirtazanine
Avanza
MFCD00865427
MIRTAZAPINE ANHYDRUOS
EINECS 288-060-6

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
432.4±45.0 °C at 760 mmHg

[ Melting Point ]:
114-116ºC

[ Molecular Formula ]:
C₁₇H₁₉N₃

[ Molecular Weight ]:
265.353

[ Flash Point ]:
215.3±28.7 °C

[ Exact Mass ]:
265.157898

[ PSA ]:
19.37000

[ LogP ]:
2.75

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.668

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
DMSO: ~8 mg/mL, soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H336

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol
rac-1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepin-10-ol
1-Oxo Mirtazapine (Mirtazapine Impurity C)
1-(3-Cyano-2-pyridyl)-4-methyl-2-phenylpiperazine
2-Chloro-3-cyanopyridine
1-Methyl-3-phenylpiperazine
1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine

DownStream

8-Hydroxy Mirtazapine
()-1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine maleate (1:1)
Mirtazapine Bromide

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.

Biochem. Pharmacol. 95 , 311-23, (2015)

Different lines of evidence indicate that the lysophosphatidic acid (LPA) receptor LPA1 is involved in neurogenesis, synaptic plasticity and anxiety-related behavior, but little is known on whether th...

Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014)

• The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail.

Analysis of drugs in plasma samples from schizophrenic patients by column-switching liquid chromatography-tandem mass spectrometry with organic-inorganic hybrid cyanopropyl monolithic column.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 993-994 , 26-35, (2015)

This study reports on the development of a rapid, selective, and sensitive column-switching liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyze sixteen drugs (antidepressants, ...

Mirtazapine
Mirtazapine
Mirtazapine
mirtazapine
Mirtazapine-d4
Mirtazapine D3
tert-butyl N-{5-[1-(aminooxy)-2-methylpropan-2-yl]-2-methylphenyl}carbamate
3-{5-[(Dimethylamino)methyl]-1,3-thiazol-2-yl}propan-1-amine
1-[(Difluoromethyl)sulfanyl]-4-(1-ethynylcyclopropyl)benzene
3-methyl-5H,6H,8H-imidazo[2,1-c][1,4]oxazine-2-sulfonyl chloride
1-(5-Bromo-2-chloropyridin-3-yl)-2-(methylamino)ethan-1-ol
3-Amino-2-(1-phenylcyclopropyl)propanoic acid
3-[2-(4-Fluorophenyl)ethyl]-2,2-dimethylcyclopropan-1-amine
2-(1,1-Difluoro-3-hydroxypropyl)benzonitrile
3-[3-Chloro-4-(trifluoromethyl)phenoxy]piperidine
tert-butyl N-(2-azido-3-hydroxypropyl)-N-(propan-2-yl)carbamate

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