Mirtazapine

Modify Date: 2024-01-02 16:31:30

Mirtazapine structure	Common Name	Mirtazapine
	CAS Number	85650-52-8	Molecular Weight	265.353
	Density	1.2±0.1 g/cm3	Boiling Point	432.4±45.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₉N₃	Melting Point	114-116ºC
	MSDS	Chinese USA	Flash Point	215.3±28.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Mirtazapine

Mirtazapine is a potent tetracyclic antidepressant.Target: 5-HT ReceptorMirtazapine, the novel antidepressant, has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors [1].Mirtazapine appears to have a substantial ameliorating effect on hot flushes and perspiration bouts. It is postulated that the 5-HT(2A) blocking properties of mirtazapine is accounted in the symptomatic relief of hot flushes [2]. After 4-24 weeks of treatment, mirtazapine induced downregulation of platelet alpha(2A)-adrenoceptors (up to 34%) and Galphai proteins (up to 28%), and the upregulation of GRK 2 (up to 30%). Treatment with mirtazapine reversed this abnormality and induced downregulation of alpha(2A)-adrenoceptor/Galphai complex [3].

Name	Mirtazapine
Synonym	More Synonyms

Description	Mirtazapine is a potent tetracyclic antidepressant.Target: 5-HT ReceptorMirtazapine, the novel antidepressant, has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors [1].Mirtazapine appears to have a substantial ameliorating effect on hot flushes and perspiration bouts. It is postulated that the 5-HT(2A) blocking properties of mirtazapine is accounted in the symptomatic relief of hot flushes [2]. After 4-24 weeks of treatment, mirtazapine induced downregulation of platelet alpha(2A)-adrenoceptors (up to 34%) and Galphai proteins (up to 28%), and the upregulation of GRK 2 (up to 30%). Treatment with mirtazapine reversed this abnormality and induced downregulation of alpha(2A)-adrenoceptor/Galphai complex [3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
References	[1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64. [2]. Waldinger, M.D., H.H. Berendsen, and D.H. Schweitzer, Treatment of hot flushes with mirtazapine: four case reports. Maturitas, 2000. 36(3): p. 165-8. [3]. Garcia-Sevilla, J.A., et al., Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment. Neuropsychopharmacology, 2004. 29(3): p. 580-8.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Research Areas >> Neurological Disease

References

[1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64.

[2]. Waldinger, M.D., H.H. Berendsen, and D.H. Schweitzer, Treatment of hot flushes with mirtazapine: four case reports. Maturitas, 2000. 36(3): p. 165-8.

[3]. Garcia-Sevilla, J.A., et al., Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment. Neuropsychopharmacology, 2004. 29(3): p. 580-8.

Density	1.2±0.1 g/cm3
Boiling Point	432.4±45.0 °C at 760 mmHg
Melting Point	114-116ºC
Molecular Formula	C₁₇H₁₉N₃
Molecular Weight	265.353
Flash Point	215.3±28.7 °C
Exact Mass	265.157898
PSA	19.37000
LogP	2.75
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.668
Storage condition	Store at RT
Water Solubility	DMSO: ~8 mg/mL, soluble

Mirtazapine MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H336
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

2-(4-Methyl-2-p...

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Mirtazapine

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Literature: Singer, Claude; Liberman, Anita; Finkelstein, Nina Patent: US2001/51718 A1, 2001 ; Title/Abstract Full Text Show Details Singer, Claude; Liberman, Anita; Finkelstein, Nina Patent: US2003/69417 A1, 2003 ;

rac-1,2,3,4,10,...

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~82%

Mirtazapine

CAS#:85650-52-8

Literature: N.V. ORGANON Patent: WO2008/125578 A2, 2008 ; Location in patent: Page/Page column 16 ;

1-Oxo Mirtazapi...

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Mirtazapine

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Literature: N.V. Organon Patent: US2008/255349 A1, 2008 ; Location in patent: Page/Page column 9 ;

(10,11-dihydro-...

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Mirtazapine

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Literature: WO2008/125577 A1, ; Page/Page column 22 ;

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Mirtazapine

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Mirtazapine

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Mirtazapine

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1-(3-Carboxypyr...

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Mirtazapine

CAS#:85650-52-8

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Precursor 7
CAS#:61337-89-1 2-(4-Methyl-2-p... CAS#:1071838-96-4 rac-1,2,3,4,10,... CAS#:191546-96-0 1-Oxo Mirtazapi... CAS#:61337-88-0 1-(3-Cyano-2-py...
CAS#:6602-54-6 2-Chloro-3-cyan... CAS#:5271-27-2 1-Methyl-3-phen... CAS#:61338-13-4 1-(3-Carboxypyr...
DownStream 3
CAS#:102335-57-9 8-Hydroxy Mirta... CAS#:85650-53-9 ()-1,2,3,4,10,1... CAS#:61337-86-8 Mirtazapine Bromide

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.

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Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-

Zispin

(14bR)-2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO[2.1-A]PYRIDO[2.3-C][2]BENZAZEPINE

Mirtazapin

1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO[2,1-A]PYRIDO[2,3-C][2]BENZAZEPINE

Remeron

ORG-3770

UNII:A051Q2099Q

2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

MIRTAZEPINE

2-Methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine

Mirtazanine

Avanza

MFCD00865427

MIRTAZAPINE ANHYDRUOS

EINECS 288-060-6

DC Chemicals Limited
China
Product Name: Mirtazapine (Remeron, Avanza)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Mirtazapine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: USP grade Mirtazapine API
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $207/10mM*1mLinDMSO

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Mirtazapine

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