Pravastatin Lactone

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Names

[ Name ]:
Pravastatin Lactone

[Synonym ]:
Butanoic acid, 2-methyl-, (1S,3S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
[14C]-Pravastatin lactone
UNII:JBE3Z4192Q
Pravastatin lactone
Pravastatin sodium specified impurity D [EP]
pravastatin
UNII-JBE3Z4192Q
(1S,3S,7S,8S,8aR)-3-Hydroxy-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate
HMS2090H21

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
590.5±50.0 °C at 760 mmHg

[ Melting Point ]:
140-143ºC

[ Molecular Formula ]:
C₂₃H₃₄O₆

[ Molecular Weight ]:
406.51

[ Flash Point ]:
199.5±23.6 °C

[ Exact Mass ]:
406.235535

[ PSA ]:
93.06000

[ LogP ]:
1.71

[ Vapour Pressure ]:
0.0±3.8 mmHg at 25°C

[ Index of Refraction ]:
1.548

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(1S,4S)-1-((R)-2-(benzyloxy)but-3-en-1-yl)-4-methylcyclohex-2-enol
8-methyl-3-phenylmethoxy-1-oxaspiro[4.5]dec-6-en-2-ol
(1S,3R,7S,8S,8aR)-8-(2-((2R,4R,6S)-4-hydroxy-6-methoxytetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalene-1,3-diol
2-((1S,6S)-3-((R)-2-(benzyloxy)-4-oxobutyl)-6-methylcyclohex-2-en-1-yl)-N,N-dimethylacetamide

DownStream

Related Compounds

Pravastatin Lactone-d3
3β-Hydroxy Pravastatin Lactone
3α-Hydroxy Pravastatin Lactone-d3
6-epi Pravastatin LactoneDiscontinued
Pravastatin Lactone Di-(tert-butyldimethylsilyl) Ether
Homopravastatin Lactone Di-(tert-butyldimethylsilyl) Ether