Pravastatin Lactone

Modify Date: 2024-01-09 22:08:39

Pravastatin Lactone Structure
Pravastatin Lactone structure
Common Name Pravastatin Lactone
CAS Number 85956-22-5 Molecular Weight 406.51
Density 1.2±0.1 g/cm3 Boiling Point 590.5±50.0 °C at 760 mmHg
Molecular Formula C23H34O6 Melting Point 140-143ºC
MSDS N/A Flash Point 199.5±23.6 °C

 Use of Pravastatin Lactone


Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis[1].

 Names

Name [(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
Synonym More Synonyms

 Pravastatin Lactone Biological Activity

Description Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis[1].
Related Catalog
References

[1]. Corsini A, et, al. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol Res. 1995 Jan;31(1):9-27.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 590.5±50.0 °C at 760 mmHg
Melting Point 140-143ºC
Molecular Formula C23H34O6
Molecular Weight 406.51
Flash Point 199.5±23.6 °C
Exact Mass 406.235535
PSA 93.06000
LogP 1.71
Vapour Pressure 0.0±3.8 mmHg at 25°C
Index of Refraction 1.548

 Synthetic Route

 Synonyms

Butanoic acid, 2-methyl-, (1S,3S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3-hydroxy-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
[14C]-Pravastatin lactone
UNII:JBE3Z4192Q
Pravastatin lactone
Pravastatin sodium specified impurity D [EP]
pravastatin
UNII-JBE3Z4192Q
(1S,3S,7S,8S,8aR)-3-Hydroxy-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate
HMS2090H21