2-carboxy-1-naphthol

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Names

[ CAS No. ]:
86-48-6

[ Name ]:
2-carboxy-1-naphthol

[Synonym ]:
2-Naphthalenecarboxylic acid, 1-hydroxy-
2-carboxy-1-naphthol
1-Hydroxy-2-naphthoic acid
EINECS 201-674-0
1-hydroxynaphthalene-2-carboxylic acid
MFCD00003960
1-hydroxy-2-naphthalenecarboxylic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
367.7±25.0 °C at 760 mmHg

[ Melting Point ]:
195-200 °C (dec.)(lit.)

[ Molecular Formula ]:
C11H8O3

[ Molecular Weight ]:
188.179

[ Flash Point ]:
190.4±19.7 °C

[ Exact Mass ]:
188.047348

[ PSA ]:
57.53000

[ LogP ]:
3.29

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.716

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
SOLUBLE IN HOT WATER

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29182910

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Naphthalenol
  • Magnesium methyl carbonate solution
  • Carbon dioxide
  • Potassium hydrogen carbonate
  • sodium 1-naphtholate
  • 7-Bromo-6-hydroxy-2,3-benzotropon
  • 2-Brom- 2-chlor-4,5-benzocyclohepta-4,6-dien-1,3-dion

DownStream

  • 1-hydroxy-N-(3-methoxyphenyl)naphthalene-2-carboxamide
  • 1,4-Dihydroxy-2-naphthoic acid
  • Martius Yellow
  • METHYL 1-HYDROXY-2-NAPHTHOATE
  • 3-[(1-hydroxynaphthalene-2-carbonyl)amino]benzoic acid
  • 1-Naphthalenol
  • benzo[g][1,3]benzodioxole
  • Methanone,(1-hydroxy-2-naphthalenyl)-1-piperidinyl-

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Hydroxynaphthoic acids identified in a high throughput screening potently ameliorate endoplasmic reticulum stress as novel chemical chaperones.

Chem. Pharm. Bull. 61(7) , 740-6, (2013)

Folding of newly synthesized protein occurs in endoplasmic reticulum (ER) and is assisted by chaperone molecules. In ER stress conditions, misfolded proteins are enriched in a lumen of ER perturbing i...

Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.

Bioorg. Med. Chem. 15 , 6535-48, (2007)

A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic ac...

Sorption of two aromatic acids onto iron oxides: experimental study and modeling.

J. Colloid. Interface Sci. 309(2) , 419-28, (2007)

The transport of aromatic carboxylate compounds in the environment can be strongly influenced by adsorption onto certain minerals, such as iron oxides and hydroxides, found in ground water and soils. ...


More Articles

Related Compounds

  • 2-(Carboxymethyl)-1-cyclohexene-1-carboxylic acid
  • 2-carboxy-1,N6-etheno adenosine 3',5'-cyclic phosphate
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  • 2-CARBOXY-1-METHYL-5-(METHYLSULFANYL)PYRIDINIUM
  • 3-(carboxymethyl)-1-methyl-1H-indole-2-carboxylic acid
  • 2-Carboxy-1-cyclopentene-1-acetic acid