2-carboxy-1-naphthol
2-carboxy-1-naphthol structure
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Common Name | 2-carboxy-1-naphthol | ||
|---|---|---|---|---|
| CAS Number | 86-48-6 | Molecular Weight | 188.179 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 367.7±25.0 °C at 760 mmHg | |
| Molecular Formula | C11H8O3 | Melting Point | 195-200 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 190.4±19.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Hydroxynaphthoic acids identified in a high throughput screening potently ameliorate endoplasmic reticulum stress as novel chemical chaperones.
Chem. Pharm. Bull. 61(7) , 740-6, (2013) Folding of newly synthesized protein occurs in endoplasmic reticulum (ER) and is assisted by chaperone molecules. In ER stress conditions, misfolded proteins are enriched in a lumen of ER perturbing its normal function, which triggers cellular self-defense me... |
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Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.
Bioorg. Med. Chem. 15 , 6535-48, (2007) A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic acid derivatives were potent inhibitors of PTP1B. Of those de... |
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Sorption of two aromatic acids onto iron oxides: experimental study and modeling.
J. Colloid. Interface Sci. 309(2) , 419-28, (2007) The transport of aromatic carboxylate compounds in the environment can be strongly influenced by adsorption onto certain minerals, such as iron oxides and hydroxides, found in ground water and soils. Batch experiments with five iron oxides were conducted to q... |
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Heterologous expression and characterization of two 1-hydroxy-2-naphthoic acid dioxygenases from Arthrobacter phenanthrenivorans.
Appl. Environ. Microbiol. 78(3) , 621-7, (2012) A protein fraction exhibiting 1-hydroxy-2-naphthoic acid (1-H2NA) dioxygenase activity was purified via ion exchange, hydrophobic interactions, and gel filtration chromatography from Arthrobacter phenanthrenivorans sp. nov. strain Sphe3 isolated from a Greek ... |
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The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate.
FEBS J. 280(7) , 1643-52, (2013) The salicylate 1,2-dioxygenase (SDO) from the bacterium Pseudaminobacter salicylatoxidans BN12 is a versatile gentisate 1,2-dioxygenase (GDO) that converts both gentisate (2,5-dihydroxybenzoate) and various monohydroxylated substrates. Several variants of thi... |
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Purification and characterization of a salicylate hydroxylase involved in 1-hydroxy-2-naphthoic acid hydroxylation from the naphthalene and phenanthrene-degrading bacterial strain Pseudomonas putida BS202-P1.
Biodegradation 12(3) , 179-88, (2001) 1-Hydroxy-2-naphthoate is formed as an intermediate in the bacterial degradation of phenanthrene. A monooxygenase which catalyzed the oxidation of 1-hydroxy-2-naphthoate to 1,2-dihydroxynaphthalene was purified from the phenanthrene- and naphthalene-degrading... |
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Influence of EDA-pi interactions in drug encapsulation using nanospheres.
Chem. Commun. (Camb.) (23) , 2689-91, (2004) We have evaluated the influence of aromatic and hydrophobic interactions on the strength and selectivity of encapsulation using polymeric nanospheres. |
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Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.
Biochemistry 48(40) , 9590-8, (2009) The small molecule component of chromoprotein enediyne antitumor antibiotics is biosynthesized through a convergent route, incorporating amino acid, polyketide, and carbohydrate building blocks around a central enediyne hydrocarbon core. The naphthoic acid mo... |
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Biodegradation of phenanthrene by Alcaligenes sp. strain PPH: partial purification and characterization of 1-hydroxy-2-naphthoic acid hydroxylase.
FEMS Microbiol. Lett. 311(1) , 93-101, (2010) Alcaligenes sp. strain PPH degrades phenanthrene via 1-hydroxy-2-naphthoic acid (1-H2NA), 1,2-dihydroxynaphthalene (1,2-DHN), salicylic acid and catechol. Enzyme activity versus growth profile and heat stability studies suggested the presence of two distinct ... |
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Citrinin selective molecularly imprinted polymers for SPE.
J. Sep. Sci. 33(8) , 1156-60, (2010) Molecularly imprinted polymers (MIPs) for citrinin (Cit) with 1-hydroxy-2-naphthoic acid (HNA) as mimic template were prepared and the molecularly imprinted SPE method was developed for the detection of Cit in rice with HPLC. The adsorption properties of HNA ... |