7-Ethyl-10-hydroxycamptothecin

Suppliers

Names

[ Name ]:
7-Ethyl-10-hydroxycamptothecin

[Synonym ]:
7-Ethyl-10-Hydroxycamptothecin(SN-38)
(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
SN-38
MFCD06762720
SN38
7-Ethyl-10-hydroxycamptothecine

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
810.3±65.0 °C at 760 mmHg

[ Melting Point ]:
217 °C

[ Molecular Formula ]:
C₂₂H₂₀N₂O₅

[ Molecular Weight ]:
392.405

[ Flash Point ]:
443.8±34.3 °C

[ Exact Mass ]:
392.137207

[ PSA ]:
101.65000

[ LogP ]:
2.31

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.738

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0491000

CAS REGISTRY NUMBER :: 86639-52-3

LAST UPDATED :: 199203

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H20-N2-O5

MOLECULAR WEIGHT :: 392.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 51,4187,1991

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25

[ Safety Phrases ]:
45

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ RTECS ]:
UQ0491000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

7-Ethylcamptothecin
1-(2-Amino-5-hydroxyphenyl)-1-propanone
(S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
7-ethyl-1,2,6,7-tetrahydro-20-(S)-camptothecin
Irinotecan hydrochloride
(S)-10-Hydroxycamptothecin
Propionaldehyde
(±)- 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy

DownStream

Customs

[ HS Code ]: 2942000000

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