PF-573228
Suppliers
Names
[ CAS No. ]:
869288-64-2
[ Name ]:
PF-573228
[Synonym ]:
6-{[4-{[3-(Methylsulfonyl)benzyl]amino}-5-(trifluoromethyl)-2-pyrimidinyl]amino}-3,4-dihydro-2(1H)-quinolinone
6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one
6-{[4-{[3-(Methylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3,4-dihydroquinolin-2(1H)-one
cc-288
2(1H)-Quinolinone, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-
PF 573228
PF573228
PF-573228
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Molecular Formula ]:
C22H20F3N5O3S
[ Molecular Weight ]:
491.486
[ Exact Mass ]:
491.123901
[ PSA ]:
121.46000
[ LogP ]:
1.03
[ Appearance of Characters ]:
white to off-white
[ Index of Refraction ]:
1.616
[ Storage condition ]:
Store at +4°C
[ Water Solubility ]:
DMSO: ≥20mg/mL
MSDS
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H319
[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338
[ Hazard Codes ]:
T
[ Risk Phrases ]:
25-36
[ Safety Phrases ]:
26-45
[ RIDADR ]:
UN 2811 6.1 / PGIII
Articles
PLoS ONE 8 , e74659, (2013)
Cell invasion through extracellular matrix (ECM) is a hallmark of the metastatic cascade. Cancer cells require adhesion to surrounding tissues for efficient migration to occur, which is mediated throu...