Gramine

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Names

[ CAS No. ]:
87-52-5

[ Name ]:
Gramine

[Synonym ]:
1H-Indole-3-methanamine, N,N-dimethyl-
Gramin
Donaxine
Indole, 3-[(dimethylamino)methyl]-
Indole,3-[(dimethylamino)methyl]
Gramine
MFCD00005629
3-(Dimethylaminomethyl)indole
Indol-3-ylmethyldimethylamine
EINECS 201-749-8
Donaxin
N,N-dimethyl-1H-indole-3-methanamine
3-(N,N-dimethylaminomethyl) indole
N-(1H-indol-3-ylmethyl)-N,N-dimethylamine
1H-Indole-3-methanamine,N,N-dimethyl
1-(1H-Indol-3-yl)-N,N-dimethylmethanamine
3-[(Dimethylamino)methyl]indole
(indol-3-ylmethyl)dimethylamine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
293.9±15.0 °C at 760 mmHg

[ Melting Point ]:
132-134 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₄N₂

[ Molecular Weight ]:
174.242

[ Flash Point ]:
131.5±20.4 °C

[ Exact Mass ]:
174.115692

[ PSA ]:
19.03000

[ LogP ]:
1.90

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.631

[ Storage condition ]:
Refrigerator (+4°C)

[ Water Solubility ]:
PRACTICALLY INSOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL7525000

CHEMICAL NAME :: Indole, 3-((dimethylamino)methyl)-

CAS REGISTRY NUMBER :: 87-52-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H14-N2

MOLECULAR WEIGHT :: 174.27

WISWESSER LINE NOTATION :: T56 BMJ D1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,11,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 16,385,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 105,130,1952 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 127 gm/kg/3W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in both tubules and glomeruli Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 18,125,1980

Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S45-S36/37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NL7525000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Indole
Formaldehyde
Dimethylamine
N,N-Dimethylmethyleneiminium chloride
Bis(dimethylamino)methane
N,N-dimethyl-1H-indole-3-carboxamide
Indole-3-carboxaldehyde
1-ethoxy-N,N-dimethyl-methanamine
3-Methylindole

DownStream

Indole-3-carboxaldehyde
(4-Methoxy-1H-indol-3-yl)acetonitrile
1H-indol-3-ylmethyl-trimethyl-azanium; sulfooxymethane
3-Methylindole
4-Bromotryptophan
Methyl 3-(dimethylamino)acrylate
DL-INDOLE-3-LACTIC ACID
3-Iodo-1-(phenylsulfonyl)-1H-indole
2-(5-chloro-1H-indol-3-yl)acetonitrile
3-Indoleacetic acid

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Response of animals to dietary gramine. I. Performance and selected hematological, biochemical and histological parameters in growing chicken, rats and pigs.

Arch. Tierernahr. 55(1) , 1-16, (2001)

The effects of feeding varied levels of low- and high-gramine yellow lupin seeds (LG and HG, respectively), and of synthetic gramine added to the diets in amounts ranging from 0.15 to 1.2 g per kg wer...