Gramine

Modify Date: 2025-08-20 15:19:05

Gramine structure	Common Name	Gramine
	CAS Number	87-52-5	Molecular Weight	174.242
	Density	1.1±0.1 g/cm3	Boiling Point	293.9±15.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₄N₂	Melting Point	132-134 °C(lit.)
	MSDS	Chinese USA	Flash Point	131.5±20.4 °C

Use of Gramine

Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].

Name	1-(1H-indol-3-yl)-N,N-dimethylmethanamine
Synonym	More Synonyms

Description	Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adiponectin Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cancer Research Areas >> Infection Research Areas >> Metabolic Disease Natural Products >> Alkaloid
Target	IC50: 3.2 µM (AdipoR2), 4.2 µM (AdipoR1)[1]
In Vitro	Gramine is an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively[1]. Gramine is a potential β2-AR agonist[2]. Gramine (20 µM to 1.2 nM) dose-dependently inhibits the growth of AdipoR1/adipoR2-positive cancer cell lines (MDA-MB-231 and MCF-7 cells), with IC50s of 9.6±0.9 and 0.1±0.1 µM, respectively[1].
References	[1]. Sun Y, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354. [2]. Chikazawa M, et al. Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle. J Nutr Sci Vitaminol (Tokyo). 2018;64(1):68-74.

Density	1.1±0.1 g/cm3
Boiling Point	293.9±15.0 °C at 760 mmHg
Melting Point	132-134 °C(lit.)
Molecular Formula	C₁₁H₁₄N₂
Molecular Weight	174.242
Flash Point	131.5±20.4 °C
Exact Mass	174.115692
PSA	19.03000
LogP	1.90
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.631
InChIKey	OCDGBSUVYYVKQZ-UHFFFAOYSA-N
SMILES	CN(C)Cc1c[nH]c2ccccc12
Storage condition	Refrigerator (+4°C)
Water Solubility	PRACTICALLY INSOLUBLE

Gramine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL7525000

CHEMICAL NAME :: Indole, 3-((dimethylamino)methyl)-

CAS REGISTRY NUMBER :: 87-52-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H14-N2

MOLECULAR WEIGHT :: 174.27

WISWESSER LINE NOTATION :: T56 BMJ D1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,11,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 16,385,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 105,130,1952 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 127 gm/kg/3W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in both tubules and glomeruli Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 18,125,1980

Hazard Codes	Xi:Irritant;
Risk Phrases	R36
Safety Phrases	S45-S36/37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	NL7525000
HS Code	2933990090

Precursor 9
CAS#:120-72-9 Indole CAS#:50-00-0 Formaldehyde CAS#:124-40-3 Dimethylamine CAS#:30354-18-8 N,N-Dimethylmet...
CAS#:51-80-9 Bis(dimethylami... CAS#:27409-13-8 N,N-dimethyl-1H... CAS#:487-89-8 Indole-3-carbox... CAS#:62992-33-0 1-ethoxy-N,N-di...
CAS#:83-34-1 3-Methylindole
DownStream 10
CAS#:487-89-8 Indole-3-carbox... CAS#:4837-74-5 (4-Methoxy-1H-i... CAS#:19260-03-8 1H-indol-3-ylme... CAS#:83-34-1 3-Methylindole
CAS#:25796-04-7 4-Bromotryptophan CAS#:999-59-7 Methyl 3-(dimet... CAS#:832-97-3 DL-INDOLE-3-LAC... CAS#:80360-14-1 3-Iodo-1-(pheny...
CAS#:81630-83-3 2-(5-chloro-1H-... CAS#:87-51-4 3-Indoleacetic acid

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol.

Proc. Natl. Acad. Sci. U. S. A. 112 , 8296-301, (2015)

Tramadol, previously only known as a synthetic analgesic, has now been found in the bark and wood of roots of the African medicinal tree Nauclea latifolia. At present, no direct evidence is available ...

NMR-titrations with complexes between ds-DNA and indole derivatives including tryptophane containing peptides.

FEBS Lett. 374(3) , 387-92, (1995)

It is shown that NMR titrations can be used on a quantitative basis to derive binding constants and binding modes of ds-DNA ligand complexes from several signals. The results are partially at variance...

Response of animals to dietary gramine. I. Performance and selected hematological, biochemical and histological parameters in growing chicken, rats and pigs.

Arch. Tierernahr. 55(1) , 1-16, (2001)

The effects of feeding varied levels of low- and high-gramine yellow lupin seeds (LG and HG, respectively), and of synthetic gramine added to the diets in amounts ranging from 0.15 to 1.2 g per kg wer...

Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: USP8 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 8
External Id: USP8 FAST DUB HTS Primary

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: USP17 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 17 like family member 5
External Id: USP17 FAST DUB HTS Primary

Name: USP7 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 7
External Id: USP7 FAST DUB HTS Primary

Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979

Name: Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Meas...
Source: Broad Institute
Target: FGF22 human recombinant
External Id: 7012-04_Inhibitor_Dose_CherryPick_Activity

Total 159, Current Page 1 of 16

Gramin

Donaxine

Indole,3-[(dimethylamino)methyl]

Gramine

MFCD00005629

3-(Dimethylaminomethyl)indole

Indol-3-ylmethyldimethylamine

EINECS 201-749-8

Donaxin

N,N-dimethyl-1H-indole-3-methanamine

3-(N,N-dimethylaminomethyl) indole

N-(1H-indol-3-ylmethyl)-N,N-dimethylamine

1H-Indole-3-methanamine,N,N-dimethyl

1-(1H-Indol-3-yl)-N,N-dimethylmethanamine

3-[(Dimethylamino)methyl]indole

(indol-3-ylmethyl)dimethylamine

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Gramine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Gramine
Price: ￥Inquiry/5mg
Purity: 97.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Gramine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Gramine
Price: ￥128.0/20mg
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

Get all suppliers and price by the below link:

Gramine suppliers

Price: ￥176/25g

Reference only. check more Gramine price

Gramine

Use of Gramine

Names

Gramine Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles26

GramineBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.