4-Amino-1-Boc-piperidine

Names

[ Name ]:
4-Amino-1-Boc-piperidine

[Synonym ]:
2-Methyl-2-propanyl 4-amino-1-piperidinecarboxylate
tert-butyl 4-aminopiperidine-1-carboxylate
MFCD01076201
N-BOC-4-amino-piperidine

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
277.3±33.0 °C at 760 mmHg

[ Melting Point ]:
50°C

[ Molecular Formula ]:
C₁₀H₂₀N₂O₂

[ Molecular Weight ]:
200.278

[ Flash Point ]:
121.5±25.4 °C

[ Exact Mass ]:
200.152481

[ PSA ]:
55.56000

[ LogP ]:
0.67

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.484

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S22-S222636/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

TERT-BUTYL 4-(BENZYLAMINO)PIPERIDINE-1-CARBOXYLATE
N-(tert-Butoxycarbonyl)-4-piperidone
tert-Butyl 4-(hydroxyimino)piperidine-1-carboxylate
1,1-dimethylethyl 4-[bis(phenylmethyl)amino]-1-piperidinecarboxylate
4-Piperidinamine
Di-tert-butyl dicarbonate
tert-butyl 4-azidopiperidine-1-carboxylate(SALTDATA: FREE)
TERT-BUTYL 4-(2,2,2-TRIFLUOROACETAMIDO)PIPERIDINE-1-CARBOXYLATE
Benzaldehyde

DownStream

1-BENZYL-2-AMINOPIPERIDINE
TERT-BUTYL 4-(4-METHOXYANILINO)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
4-(6-Chloro-pyrimidin-4-ylamino)-piperidine-1-carboxylicacidtert-butylester
TERT-BUTYL 4-(2-OXO-4-PHENYL-2,3-DIHYDRO-1H-IMIDAZOL-1-YL)PIPERIDINE-1-CARBOXYLATE
1-BOC-4-CYCLOHEXYLAMINO-PIPERIDINE
TERT-BUTYL 4-(2-PYRIMIDINYLAMINO)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
TERT-BUTYL 4-(BENZYLAMINO)PIPERIDINE-1-CARBOXYLATE
1-BOC-4-(ISOPROPYLAMINO)PIPERIDINE
tert-Butyl 4-((6-bromopyridin-2-yl)amino)piperidine-1-carboxylate
2-(2-fluorophenyl)-N-piperidin-4-ylacetamide

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Annulation of primary amines to piperazines and diazaspirocycles utilizing alpha-methyl benzyl resin.

J. Comb. Chem. 8 , 132, (2006)

The microwave-assisted solid-phase synthesis of piperazines, 3,9-diazaspiro[5.5]undecanes and 2,9-diazaspiro[5.5]undecanes is reported. The synthesis relies on the direct annulation of primary amines ...

4-AMINO-1-BOC-PIPERIDINE-HCl
4-Amino-1-Boc-piperidine-4-carboxylic acid
Methyl 4-amino-1-Boc-piperidine-4-carboxylate
4-AMINO-1-PIPERIDINE-ETHANOL
Cis-4-amino-1-Boc-3-methoxy-piperidine
Trans-4-amino-1-boc-3-hydroxypiperidine
1-(5-methyl-1H-pyrazol-3-yl)-4-oxocyclohexane-1-carboxylic acid
1-(5-methyl-1H-pyrazol-3-yl)-3-oxocyclobutane-1-carbonitrile
methyl (3R)-3-(4-fluoro-3-nitrophenyl)-3-hydroxypropanoate
3-Fluoro-4-[(3-methylazetidin-3-yl)oxy]phenol
5-(2-Fluoro-4-hydroxyphenyl)-1,3-oxazolidin-2-one
4-[1-(2-Aminopropan-2-yl)cyclopropyl]-3-fluorophenol
2-(Hydrazinylmethyl)-4-nitrophenol
2-[1-(Hydroxymethyl)cyclobutyl]-4-nitrophenol
2-{[Hydroxy(methyl)amino]methyl}-4-nitrophenol
1-{2-[4-(Propan-2-yl)phenyl]propan-2-yl}cyclopropan-1-amine

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