SC-66

Names

[ Name ]:
SC-66

[Synonym ]:
Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)-
(2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
SC-66
SC66

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
514.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₆N₂O

[ Molecular Weight ]:
276.332

[ Flash Point ]:
260.0±36.5 °C

[ Exact Mass ]:
276.126251

[ PSA ]:
42.85000

[ LogP ]:
3.03

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.683

[ Storage condition ]:
-20℃

MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells.

Oncotarget 6(3) , 1707-22, (2015)

Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent ma...

p22phox confers resistance to cisplatin, by blocking its entry into the nucleus.

Oncotarget 6(6) , 4110-25, (2015)

Cisplatin (CDDP) is a potent chemotherapeutic agent but resistance to the drug remains a major challenge in cancer treatment. To evaluate the efficacy of CDDP in oral squamous cell carcinoma (OSCC), w...

PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.

Cell. Signal. 27 , 1478-87, (2015)

Proliferating cell nuclear antigen (PCNA), commonly known as a nuclear protein essential for regulation of DNA replication, DNA repair, and epigenetics, has recently been associated with multiple cyto...

SC-66

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Names

Chemical & Physical Properties

MSDS

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Safety Information

Articles

Related Compounds