3-demethylthiocolchicine
Suppliers
Names
[ CAS No. ]:
87424-25-7
[ Name ]:
3-demethylthiocolchicine
[Synonym ]:
N-((S)-3-Hydroxy-1,2-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid
Acetamide,N-(5,6,7,9-tetrahydro-1,2-dimethoxy-3-hydroxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-,(S)
3-Desmethylthiocolchicine
(S)-7-Acetylamino-3-hydroxy-1,2-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on
Colchicine,O(sup 3)-demethyl-10-thio
O(sup 3)-Demethyl-10-thiocolchicine
Acetamide,N-((7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)
(S) N-[1,2-dimethoxy-3-hydroxy-10-methylthio-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]-acetamide
3-demethylthiocolchicine
3-O-demethylthiocolchicine
N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
2-Demethylthio-colchicine
N-((S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
Chemical & Physical Properties
[ Density]:
1.33g/cm3
[ Boiling Point ]:
769ºC at 760 mmHg
[ Melting Point ]:
>240ºC (dec.)
[ Molecular Formula ]:
C21H23NO5S
[ Molecular Weight ]:
401.47600
[ Flash Point ]:
418.9ºC
[ Exact Mass ]:
401.13000
[ PSA ]:
110.16000
[ LogP ]:
3.67280
[ Index of Refraction ]:
1.636
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AC8586000
- CHEMICAL NAME :
- Acetamide, N-(5,6,7,9-tetrahydro-1,2-dimethoxy-3-hydroxy-10-(met hylthio)-9-oxobenzo(a) heptalen-7-yl)-, (S)-
- CAS REGISTRY NUMBER :
- 87424-25-7
- BEILSTEIN REFERENCE NO. :
- 3176383
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H23-N-O5-S
- MOLECULAR WEIGHT :
- 401.51
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 28,1204,1985