3-demethylthiocolchicine
3-demethylthiocolchicine structure
|
Common Name | 3-demethylthiocolchicine | ||
|---|---|---|---|---|
| CAS Number | 87424-25-7 | Molecular Weight | 401.47600 | |
| Density | 1.33g/cm3 | Boiling Point | 769ºC at 760 mmHg | |
| Molecular Formula | C21H23NO5S | Melting Point | >240ºC (dec.) | |
| MSDS | N/A | Flash Point | 418.9ºC | |
| Name | N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
|---|---|
| Synonym | More Synonyms |
| Density | 1.33g/cm3 |
|---|---|
| Boiling Point | 769ºC at 760 mmHg |
| Melting Point | >240ºC (dec.) |
| Molecular Formula | C21H23NO5S |
| Molecular Weight | 401.47600 |
| Flash Point | 418.9ºC |
| Exact Mass | 401.13000 |
| PSA | 110.16000 |
| LogP | 3.67280 |
| Index of Refraction | 1.636 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
|
~58%
3-demethylthioc... CAS#:87424-25-7 |
| Literature: ALBERTA HEALTH SERVICES; NATIONAL RESEARCH COUNCIL OF CANADA; TUSZYNSKI, Jack; MANE, Jonathan Y.; HUZIL, John Torin; TOMANEK, Boguslaw; BARTUSIK, Darota Patent: WO2011/22805 A1, 2011 ; Location in patent: Page/Page column 78 ; |
|
~64%
3-demethylthioc... CAS#:87424-25-7 |
| Literature: Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372 |
|
~95%
3-demethylthioc... CAS#:87424-25-7 |
| Literature: The United States of America as represented by the Department of Health and Human Services Patent: US4692463 A1, 1987 ; |
|
~%
3-demethylthioc... CAS#:87424-25-7 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 1 p. 235 - 238 |
|
~%
3-demethylthioc... CAS#:87424-25-7 |
| Literature: WO2011/22805 A1, ; |
|
~%
3-demethylthioc... CAS#:87424-25-7 |
| Literature: Bulletin de la Societe Chimique de France, , p. 755,756 Bulletin de la Societe Chimique de France, , p. 198 |
|
~%
3-demethylthioc... CAS#:87424-25-7 |
| Literature: Bulletin de la Societe Chimique de France, , p. 755,756 Bulletin de la Societe Chimique de France, , p. 198 |
| Precursor 9 | |
|---|---|
| DownStream 1 | |
| N-((S)-3-Hydroxy-1,2-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid |
| Acetamide,N-(5,6,7,9-tetrahydro-1,2-dimethoxy-3-hydroxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-,(S) |
| 3-Desmethylthiocolchicine |
| (S)-7-Acetylamino-3-hydroxy-1,2-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on |
| Colchicine,O(sup 3)-demethyl-10-thio |
| O(sup 3)-Demethyl-10-thiocolchicine |
| Acetamide,N-((7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl) |
| (S) N-[1,2-dimethoxy-3-hydroxy-10-methylthio-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl]-acetamide |
| 3-demethylthiocolchicine |
| 3-O-demethylthiocolchicine |
| N-[(7S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide |
| 2-Demethylthio-colchicine |
| N-((S)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide |