Aurora Kinase Inhibitor 3

Suppliers

Names

[ Name ]:
Aurora Kinase Inhibitor 3

[Synonym ]:
Cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide
Anilinopyrimidine1
2np8
Aurora Kinase Inhibitor III
N-{3-[(4-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]phenyl}cyclopropanecarboxamide

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈F₃N₅O

[ Molecular Weight ]:
413.39600

[ Exact Mass ]:
413.14600

[ PSA ]:
85.66000

[ LogP ]:
5.47550

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933599090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthetic lethal screen of an EGFR-centered network to improve targeted therapies.

Sci. Signal. 3 , ra67, (2010)

Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes closely linked t...

Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9.

Cancer Res. 70 , 8907-16, (2010)

Elevated expression of the NEDD9/HEF1/Cas-L scaffolding protein promotes tumor cell invasion and metastasis in multiple cancer cell types. Conversely, generation of mammary tumors in the mouse mammary...

Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library.

J. Am. Chem. Soc. 128 , 2182-2183, (2006)

The epidermal growth factor receptor (EGFR) tyrosine kinase was one of the first receptor tyrosine kinases to be targeted for drug development by the pharmaceutical industry due to its ubiquitous over...

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