Aurora Kinase Inhibitor 3
Aurora Kinase Inhibitor 3 structure
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Common Name | Aurora Kinase Inhibitor 3 | ||
|---|---|---|---|---|
| CAS Number | 879127-16-9 | Molecular Weight | 413.39600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H18F3N5O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Synthetic lethal screen of an EGFR-centered network to improve targeted therapies.
Sci. Signal. 3 , ra67, (2010) Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes closely linked to therapeutic targets would be enriched for determinants of... |
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Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9.
Cancer Res. 70 , 8907-16, (2010) Elevated expression of the NEDD9/HEF1/Cas-L scaffolding protein promotes tumor cell invasion and metastasis in multiple cancer cell types. Conversely, generation of mammary tumors in the mouse mammary tumor virus (MMTV)-polyoma virus middle T (PyVT) genetic m... |
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Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library.
J. Am. Chem. Soc. 128 , 2182-2183, (2006) The epidermal growth factor receptor (EGFR) tyrosine kinase was one of the first receptor tyrosine kinases to be targeted for drug development by the pharmaceutical industry due to its ubiquitous overexpression in a variety of tumors. Despite the validation o... |
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Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes.
J. Thorac. Cardiovasc. Surg. 284 , 5497-505, (2009) p53 is an important tumor suppressor regulating the cell cycle at multiple stages in higher vertebrates. The p53 gene is frequently deleted or mutated in human cancers, resulting in loss of p53 activity. This leads to centrosome amplification, aneuploidy, and... |