2-Methylbenzene-1-sulfonamide
Suppliers
Names
[ CAS No. ]:
88-19-7
[ Name ]:
2-Methylbenzene-1-sulfonamide
[Synonym ]:
Toluene-2-sulfonamide
o-toluenesulfonamide
Toluene-2-sulphonamide
2-Methylbenzene-1-sulphonamide
MFCD00011692
o-Methylbenzenesulfonamide.
EINECS 201-808-8
2-methylbenzene-1-sulfonamide
2-Aminosulfonyltoluene
2-Sulfamoyltoluene
2-Toluenesulfonamide
ZSWR B1
2-Methylbenzenesulfonamide
2-Tolylsulfonamide
Benzenesulfonamide, 2-methyl-
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
330.2±35.0 °C at 760 mmHg
[ Melting Point ]:
155 °C
[ Molecular Formula ]:
C7H9NO2S
[ Molecular Weight ]:
171.217
[ Flash Point ]:
153.5±25.9 °C
[ Exact Mass ]:
171.035400
[ PSA ]:
68.54000
[ LogP ]:
0.79
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.564
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XT4900000
- CHEMICAL NAME :
- o-Toluenesulfonamide
- CAS REGISTRY NUMBER :
- 88-19-7
- BEILSTEIN REFERENCE NO. :
- 1102362
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C7-H9-N-O2-S
- MOLECULAR WEIGHT :
- 171.23
- WISWESSER LINE NOTATION :
- ZSWR B1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4870 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13 gm/kg/96W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4300 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 2500 umol/L
- REFERENCE :
- 45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,111,1980 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,334,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1103 No. of Facilities: 121 (estimated) No. of Industries: 4 No. of Occupations: 4 No. of Employees: 975 (estimated) No. of Female Employees: 272 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319-H351
[ Precautionary Statements ]:
P281-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R40
[ Safety Phrases ]:
S26-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
XT5075000
[ HS Code ]:
2935009090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2935009090
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
Articles
J. Assoc. Off. Anal. Chem. 61(6) , 1528-32, (1978)
A gas-liquid chromatographic (GLC) procedure with p-toluenesulfonamide (p-TS) as an internal standard is used to determine o-toluenesulfonamide (o-TS), a major impurity in artificial sweetening substa...
J. Am. Chem. Soc. 130(31) , 10066-7, (2008)
A Pd-catalyzed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ genera...
Contact Dermatitis 33(3) , 157-64, (1995)
Nail polish that has completely dried on the fingernails contains water-soluble components that attain the skin during extensive but transient contact. This was proven by water extraction of thin laye...