2-Methylbenzene-1-sulfonamide

Modify Date: 2024-01-02 16:53:35

2-Methylbenzene-1-sulfonamide Structure
2-Methylbenzene-1-sulfonamide structure
Common Name 2-Methylbenzene-1-sulfonamide
CAS Number 88-19-7 Molecular Weight 171.217
Density 1.3±0.1 g/cm3 Boiling Point 330.2±35.0 °C at 760 mmHg
Molecular Formula C7H9NO2S Melting Point 155 °C
MSDS Chinese USA Flash Point 153.5±25.9 °C
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Names

Name o-Toluenesulfonamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 330.2±35.0 °C at 760 mmHg
Melting Point 155 °C
Molecular Formula C7H9NO2S
Molecular Weight 171.217
Flash Point 153.5±25.9 °C
Exact Mass 171.035400
PSA 68.54000
LogP 0.79
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.564

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XT4900000
CHEMICAL NAME :
o-Toluenesulfonamide
CAS REGISTRY NUMBER :
88-19-7
BEILSTEIN REFERENCE NO. :
1102362
LAST UPDATED :
199712
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C7-H9-N-O2-S
MOLECULAR WEIGHT :
171.23
WISWESSER LINE NOTATION :
ZSWR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4870 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13 gm/kg/96W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4300 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
2500 umol/L
REFERENCE :
45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,111,1980 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,334,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1103 No. of Facilities: 121 (estimated) No. of Industries: 4 No. of Occupations: 4 No. of Employees: 975 (estimated) No. of Female Employees: 272 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H319-H351
Precautionary Statements P281-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn:Harmful;
Risk Phrases R40
Safety Phrases S26-S36/37
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS XT5075000
HS Code 2935009090

 Synthetic Route

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Articles11

More Articles
Determination of o-toluenesulfonamide in artificial sweeteners containing saccharin.

J. Assoc. Off. Anal. Chem. 61(6) , 1528-32, (1978)

A gas-liquid chromatographic (GLC) procedure with p-toluenesulfonamide (p-TS) as an internal standard is used to determine o-toluenesulfonamide (o-TS), a major impurity in artificial sweetening substa...

Distinct reactivity of Pd(OTs)2: the intermolecular Pd(II)-catalyzed 1,2-carboamination of dienes.

J. Am. Chem. Soc. 130(31) , 10066-7, (2008)

A Pd-catalyzed intermolecular 1,2-carboamination route to indolines from N-aryl ureas and 1,3-dienes that proceeds under mild conditions in relatively nonacidic media, is presented. The in situ genera...

The allergens of nail polish. (I). Allergenic constituents of common nail polish and toluenesulfonamide-formaldehyde resin (TS-F-R).

Contact Dermatitis 33(3) , 157-64, (1995)

Nail polish that has completely dried on the fingernails contains water-soluble components that attain the skin during extensive but transient contact. This was proven by water extraction of thin laye...

 Synonyms

Toluene-2-sulfonamide
o-toluenesulfonamide
Toluene-2-sulphonamide
2-Methylbenzene-1-sulphonamide
MFCD00011692
o-Methylbenzenesulfonamide.
EINECS 201-808-8
2-methylbenzene-1-sulfonamide
2-Aminosulfonyltoluene
2-Sulfamoyltoluene
2-Toluenesulfonamide
ZSWR B1
2-Methylbenzenesulfonamide
2-Tolylsulfonamide
Benzenesulfonamide, 2-methyl-
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