Cilazapril

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Names

[ Name ]:
Cilazapril

[Synonym ]:
Ro 34-2848
(1S,9S)-9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
9(S)-[1-(S)-(ethoxycarbony)-3-phenylpropylamino]octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]-diazepine-1(S)-carboxylic acid
(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
Cilazaprilum [Latin]
Cilazaprilum
MFCD08459332
Cilazil
EINECS 279-694-4
Cilazapril

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
598.1ºC at 760 mmHg

[ Melting Point ]:
95-97ºC

[ Molecular Formula ]:
C₂₂H₃₁N₃O₅

[ Molecular Weight ]:
417.49900

[ Flash Point ]:
315.5ºC

[ Exact Mass ]:
417.22600

[ PSA ]:
99.18000

[ LogP ]:
1.86220

[ Vapour Pressure ]:
3.73E-15mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8°C

Safety Information

[ Safety Phrases ]:
22-24/25

[ RTECS ]:
MJ9650200

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(R)-2-Hydroxy-4-phenylbutyric acid
2(S)-4-Benzoyloxy carbonyl-2-phthalimido butyryl chloride
(S)-1-benzyl-3-tert-butyl piperazine-1,3-dicarboxylate
(S)-5-(BENZYLOXY)-2-(1,3-DIOXOISOINDOLIN-2-YL)-5-OXOPENTANOIC ACID
tert-butyl (4S,7R)-7-(1,3-dioxoisoindol-2-yl)-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylate
TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE
Ethyl (R)-2-hydroxy-4-phenylbutyrate