Bafilomycin B1

Suppliers

Names

[ CAS No. ]:
88899-56-3

[ Name ]:
Bafilomycin B1

[Synonym ]:
(5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-ox ;o-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-5-isopropyl-4-methyl-α-D-threo-pentopyranose
BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO-MYCES SPECIES
bafilomycin b1from streptomyces sp.
α-D-threo-Pentopyranose, 2,4-dideoxy-1-C-[(1S,2R,3S)-2-hydroxy-3-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-3 -O-[(2E)-4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-1,4-dioxo-2-buten-1-yl]-4-methyl-5-C-(1-methylethyl)-, (5R)-
ino)carbonyl)-2-methoxy-24-methyl
BafilomycinB1fromStreptomycesgriseus
MFCD00214150

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
939.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C44H65NO13

[ Molecular Weight ]:
815.986

[ Flash Point ]:
521.9±34.3 °C

[ Exact Mass ]:
815.445618

[ PSA ]:
207.38000

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.563

[ Storage condition ]:
−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NG8841000
CHEMICAL NAME :
Hygrolidin, 37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclo penten-1-yl)amino)car bonyl)- 2-methoxy-24-methyl-
CAS REGISTRY NUMBER :
88899-56-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C44-H65-N-O13
MOLECULAR WEIGHT :
816.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1253,1981

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H310 + H330

[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 3462 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
NG8841000

Precursor & DownStream

Precursor

DownStream

  • (E)-4-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-4-oxobut-2-enoic acid

Articles

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

Proc. Natl. Acad. Sci. U. S. A. 85 , 7972, (1988)

Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast,...

Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B1 and destruxin E.

Biochim. Biophys. Acta 1126(1) , 41-8, (1992)

Two microbial metabolites, bafilomycin B1 and destruxin E, have been found to inhibit significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets at 3 nM and 0.5 mi...

The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 beta-cells.

Cell Biol. Toxicol. 22(3) , 169-81, (2006)

Inhibition of endosomal acidification disturbs insulin signaling in both liver and adipose cells. In this study we used MIN6 beta cells to determine whether bafilomycin, a potent inhibitor of the prot...


More Articles

Related Compounds

  • Bafilomycin C1
  • bafilomycin b2
  • bafilomycin-C2
  • bafilomycin A
  • Bafilomycin A1
  • voghieroside B1
  • N-(1-cyano-1,2-dimethylpropyl)-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)prop-2-enamide
  • 3-Hydroxy-N'-[(E)-2-(4-methylphenyl)ethenyl]sulfonylbenzohydrazide
  • 4-[2-Cyano-3-(2-cyclopropyl-1,3-thiazol-4-yl)prop-2-enamido]benzoic acid
  • 6-chloro-N-[3-(propan-2-ylsulfanyl)-1H-1,2,4-triazol-5-yl]pyridine-3-carboxamide
  • 2-cyano-N-(4-methoxyphenyl)-3-{8-methylimidazo[1,2-a]pyridin-3-yl}prop-2-enamide
  • Ethyl 2-amino-4-fluoro-2,3-dihydro-1H-indene-2-carboxylate hydrochloride
  • 4-Methoxy-3-[[(E)-2-(4-methylphenyl)ethenyl]sulfonylamino]benzoic acid
  • (E)-N-(3-Cyanothiolan-3-yl)-3-(4-methoxyphenyl)but-2-enamide
  • 3-(2-tert-butyl-1,3-thiazol-5-yl)-N-(1-cyano-2-methoxy-1-methylethyl)prop-2-enamide
  • (E)-N-(2-Ethyl-4-hydroxybutyl)-2-(4-methylphenyl)ethenesulfonamide
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.